1-(4-Anilinopiperidin-1-yl)-2-(4-nitrophenyl)ethan-1-one

Base Information

Chemical Name:1-(4-Anilinopiperidin-1-yl)-2-(4-nitrophenyl)ethan-1-one
CAS No.:91742-68-6
Molecular Formula:C19H21N3O3
Molecular Weight:339.394
Hs Code.:
DSSTox Substance ID:DTXSID10539856
Wikidata:Q82415669

Synonyms:91742-68-6;DTXSID10539856;1-(4-Anilinopiperidin-1-yl)-2-(4-nitrophenyl)ethan-1-one

Suppliers and Price of 1-(4-Anilinopiperidin-1-yl)-2-(4-nitrophenyl)ethan-1-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(4-Anilinopiperidin-1-yl)-2-(4-nitrophenyl)ethan-1-one

Chemical Property:

XLogP3:3.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:339.15829154
Heavy Atom Count:25
Complexity:443

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(CCC1NC2=CC=CC=C2)C(=O)CC3=CC=C(C=C3)[N+](=O)[O-]

Technology Process of 1-(4-Anilinopiperidin-1-yl)-2-(4-nitrophenyl)ethan-1-one

There total 5 articles about 1-(4-Anilinopiperidin-1-yl)-2-(4-nitrophenyl)ethan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 91742-67-5
2-(4-Nitro-phenyl)-1-(4-phenylimino-piperidin-1-yl)-ethanone

: 91742-68-6
1-<2-(4-nitrophenyl)acetyl>-4-(phenylamino)piperidine

Guidance literature:: With sodium tetrahydroborate; In methanol; for 0.75h; Yield given;
DOI:10.1021/jm00378a008

Reference yield:

: 41979-39-9
4-piperidone hydrochloride

: 91742-68-6
1-<2-(4-nitrophenyl)acetyl>-4-(phenylamino)piperidine

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / aq. NaHCO₃ / CH₂Cl₂ / 1 h

2: p-TsOH / toluene / 5 h / Heating

3: NaBH₄ / methanol / 0.75 h

With sodium tetrahydroborate; sodium hydrogencarbonate; toluene-4-sulfonic acid; In methanol; dichloromethane; toluene;
DOI:10.1021/jm00378a008

Reference yield:

: 62-53-3
aniline

: 91742-68-6
1-<2-(4-nitrophenyl)acetyl>-4-(phenylamino)piperidine

Guidance literature:: Multi-step reaction with 2 steps

1: p-TsOH / toluene / 5 h / Heating

2: NaBH₄ / methanol / 0.75 h

With sodium tetrahydroborate; toluene-4-sulfonic acid; In methanol; toluene;
DOI:10.1021/jm00378a008