1-Epilupininic acid

Base Information

Chemical Name:1-Epilupininic acid
CAS No.:26892-59-1
Molecular Formula:C₁₀H₁₇NO₂
Molecular Weight:183.25
Hs Code.:
DSSTox Substance ID:DTXSID00428922
Nikkaji Number:J37.657D
Mol file:26892-59-1.mol

Synonyms:26892-59-1;1-Epilupininic acid;AC1ORXYT;DTXSID00428922

Suppliers and Price of 1-Epilupininic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 1-Epilupininic acid

Chemical Property:

PSA：40.54000
LogP:1.27340
XLogP3:-1.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:183.125928785
Heavy Atom Count:13
Complexity:205

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CCN2CCCC(C2C1)C(=O)O
Isomeric SMILES:C1CCN2CCC[C@@H]([C@H]2C1)C(=O)O

Technology Process of 1-Epilupininic acid

There total 13 articles about 1-Epilupininic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 725250-71-5
(1R)-(9aR)-octahydro-quinolizine-1-carboxylic acid methyl ester

: 26892-59-1
epilupininic acid

Guidance literature:: With lithium hydroxide monohydrate; In tetrahydrofuran; water; at 0 - 20 ℃; for 4h; Inert atmosphere;
DOI:10.1016/j.tet.2011.07.017

Reference yield:

: 16100-91-7,28270-22-6,57885-49-1,57885-50-4,91690-85-6,106402-28-2,106402-29-3
trans carbethoxy-1 octahydro-1,2,3,6,7,8,9,10-4H-pyrido<1,2-a>pyridine

: 574-99-2,26892-59-1,90978-66-8
(+/-)-epilupininoic acid

Guidance literature:: With ammonium hydroxide; at 140 - 150 ℃;

Reference yield:

: 1000806-51-8
(E)-(7-tert-butoxycarbonylamino)-2-heptenal

: 26892-59-1
epilupininic acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: (S)-2-{bis[3,5-bis(trifluoromethyl)phenyl][(trimethylsilanyl)oxy]methyl}pyrrolidine; benzoic acid / chloroform / 22 h / -50 °C / Inert atmosphere

2.1: sodium dihydrogenphosphate; sodium chlorite; dihydrogen peroxide / methanol; water; acetonitrile / 3 h / 0 - 20 °C / Inert atmosphere

3.1: methanol / diethyl ether; toluene / 3 h / 0 - 20 °C / Inert atmosphere

4.1: lithium diisopropyl amide / diethyl ether / 1 h / -100 °C / Inert atmosphere

4.2: 1 h / -100 °C / Inert atmosphere

5.1: dimethylsulfide borane complex / hexane / 0 °C / Inert atmosphere

5.2: 1 h / Inert atmosphere; Reflux

6.1: triethylamine / dichloromethane / 2 h / Inert atmosphere

7.1: 1.5 h / 20 °C / Inert atmosphere

8.1: sodium hydroxide / dichloromethane; water / Inert atmosphere

9.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 4 h / 0 - 20 °C / Inert atmosphere

With (S)-2-{bis[3,5-bis(trifluoromethyl)phenyl][(trimethylsilanyl)oxy]methyl}pyrrolidine; methanol; sodium chlorite; sodium dihydrogenphosphate; lithium hydroxide monohydrate; dimethylsulfide borane complex; dihydrogen peroxide; triethylamine; benzoic acid; sodium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; chloroform; water; toluene; acetonitrile; 1.1: aza-Michael reaction;
DOI:10.1016/j.tet.2011.07.017