4-HYDROXY-1-(TOLUENE-4-SULFONYL)-PYRROLIDINE-2-CARBOXYLIC ACID

Base Information

• Chemical Name: 4-HYDROXY-1-(TOLUENE-4-SULFONYL)-PYRROLIDINE-2-CARBOXYLIC ACID
• CAS No.: 20275-18-7
• Molecular Formula: C12H15NO5S
• Molecular Weight: 285.321
• Hs Code.: 2933990090
• Mol file: 20275-18-7.mol

Synonyms:trans-4-Hydroxy-N-tosyl-L-proline;(2S,4R)-4-hydroxy-N-tosylproline;N-tosyl-trans-4-hydroxy-L-proline;1-(4-Tolylsulfonyl)-4-hydroxy-L-proline;(2S,4R)-1-(p-tolylsulfonyl)-4-hydroxyproline;N--trans-4-hydroxy-L-proline;trans-4-hydroxy-1-(toluene-4-sulfonyl)-L-proline;

Chemical Property of 4-HYDROXY-1-(TOLUENE-4-SULFONYL)-PYRROLIDINE-2-CARBOXYLIC ACID

Chemical Property:

• Vapor Pressure: 9.63E-12mmHg at 25°C
• Boiling Point: 522.5°Cat760mmHg
• Flash Point: 269.8°C
• PSA: 103.29000
• Density: 1.481g/cm³
• LogP: 1.22220

Purity/Quality:

96% ^*data from raw suppliers

(4R)-4-HYDROXY-1-[(4-METHYLPHENYL)SULFONYL]-L-PROLINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-HYDROXY-1-(TOLUENE-4-SULFONYL)-PYRROLIDINE-2-CARBOXYLIC ACID

There total 3 articles about 4-HYDROXY-1-(TOLUENE-4-SULFONYL)-PYRROLIDINE-2-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

p-toluenesulfonyl chloride (98-59-9) + 4R-4-hydroxyproline (51-35-4,30724-02-8) → N--trans-4-hydroxy-L-proline (20275-18-7)

Guidance literature:

With sodium carbonate; In water; for 48h; Ambient temperature;

DOI:10.1021/jo00292a054

Reference yield: 36.0%

p-toluenesulfonyl chloride (98-59-9) + 4R-4-hydroxyproline (51-35-4,30724-02-8) → N--trans-4-hydroxy-L-proline (20275-18-7) + N,O-ditosylhydroxy-L-proline (5260-29-7)

Guidance literature:

With sodium hydroxide; In diethyl ether; water; for 4.75h; Ambient temperature;

Reference yield:

→ N--trans-4-hydroxy-L-proline (20275-18-7)

Guidance literature:

Hydroxy-L-prolin, p-Tosylchlorid, Ae., 2n NaOH (neben anderen Prod.);

upstream raw materials:

p-toluenesulfonyl chloride

4R-4-hydroxyproline

Downstream raw materials:

(1S,4S)-N-Benzyl-2,5-diazabicyclo-[2.2.1]heptane

(1S,4S)-5-Benzyl-2-tosyl-2,5-diazabicyclo<2.2.1>heptane

methyl (2S,4R)-4-hydroxy-1-(p-tolylsulfonyl)pyrrolidine-2-carboxylate

(2S)-methyl 1-(4-methylphenylsulfonyl)-3,4-dihydropyrrole-2-carboxylate