Technology Process of 1-Pyrrolidinecarboxylic acid,
2-[4-(phenylmethoxy)benzoyl]-5-(phenylmethyl)-, 1,1-dimethylethyl ester,
trans-
There total 7 articles about 1-Pyrrolidinecarboxylic acid,
2-[4-(phenylmethoxy)benzoyl]-5-(phenylmethyl)-, 1,1-dimethylethyl ester,
trans- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1) phosphorus oxychloride / 1) 5h, room temperature 2) dry 1,2-dichloroethane, 16h
2: 88 percent / potassium tert-butoxide / tetrahydrofuran / 3 h / Heating
3: 74 percent / H2 / 5percent Pt/C / methanol / 3 h / 760 Torr / Ambient temperature
4: 1N sodium hydroxide / methanol / 65 h / Heating
With
sodium hydroxide; potassium tert-butylate; hydrogen; trichlorophosphate;
platinum on activated charcoal;
In
tetrahydrofuran; methanol;
DOI:10.1021/jo00196a020
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 72 percent / lithium aluminum hydride / tetrahydrofuran / 48 h / Heating
2: 1) phosphorus oxychloride / 1) 5h, room temperature 2) dry 1,2-dichloroethane, 16h
3: 88 percent / potassium tert-butoxide / tetrahydrofuran / 3 h / Heating
4: 74 percent / H2 / 5percent Pt/C / methanol / 3 h / 760 Torr / Ambient temperature
5: 1N sodium hydroxide / methanol / 65 h / Heating
With
sodium hydroxide; lithium aluminium tetrahydride; potassium tert-butylate; hydrogen; trichlorophosphate;
platinum on activated charcoal;
In
tetrahydrofuran; methanol;
DOI:10.1021/jo00196a020
- Guidance literature:
-
Multi-step reaction with 5 steps
1: triethylamine / toluene / 1 h
2: 1) phosphorus oxychloride / 1) 5h, room temperature 2) dry 1,2-dichloroethane, 16h
3: 88 percent / potassium tert-butoxide / tetrahydrofuran / 3 h / Heating
4: 74 percent / H2 / 5percent Pt/C / methanol / 3 h / 760 Torr / Ambient temperature
5: 1N sodium hydroxide / methanol / 65 h / Heating
With
sodium hydroxide; potassium tert-butylate; hydrogen; triethylamine; trichlorophosphate;
platinum on activated charcoal;
In
tetrahydrofuran; methanol; toluene;
DOI:10.1021/jo00196a020
