Difluprednate

Base Information

• Chemical Name: Difluprednate
• CAS No.: 23674-86-4
• Molecular Formula: C27H34F2O7
• Molecular Weight: 508.56
• European Community (EC) Number: 245-815-4
• UNII: S8A06QG2QE
• DSSTox Substance ID: DTXSID0046773
• Nikkaji Number: J15.820H
• Wikipedia: Difluprednate
• Wikidata: Q736113
• NCI Thesaurus Code: C80259
• RXCUI: 23043
• Pharos Ligand ID: 1Q8SWN1ZS33F
• Metabolomics Workbench ID: 43704
• ChEMBL ID: CHEMBL1201749
• Mol file: 23674-86-4.mol

Synonyms:C.M.9155;difluprednate;ENV905;Epitopic

Chemical Property of Difluprednate

Chemical Property:

• Vapor Pressure: 6.46E-17mmHg at 25°C
• Melting Point: 192 - 194oC
• Refractive Index: 1.544
• Boiling Point: 600.3 °C at 760 mmHg
• PKA: 12.56±0.70(Predicted)
• Flash Point: 316.9 °C
• PSA: 106.97000
• Density: 1.29 g/cm³
• LogP: 3.51950
• Storage Temp.: 2-8°C
• Solubility.: Dioxane (Slightly), Methanol (Slightly)
• XLogP3: 3.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 9
• Rotatable Bond Count: 8
• Exact Mass: 508.22725974
• Heavy Atom Count: 36
• Complexity: 1050

Purity/Quality:

99% ^*data from raw suppliers

Difluprednate-d3 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CCCC(=O)OC1(CCC2C1(CC(C3(C2CC(C4=CC(=O)C=CC43C)F)F)O)C)C(=O)COC(=O)C
• Isomeric SMILES: CCCC(=O)O[C@@]1(CC[C@@H]2[C@@]1(C[C@@H]([C@]3([C@H]2C[C@@H](C4=CC(=O)C=C[C@@]43C)F)F)O)C)C(=O)COC(=O)C
• Recent ClinicalTrials: A Study of the Effect of Different Doses of Difluprednate Eye Drops on the Intraocular Pressure After Phacoemulsification
• Recent NIPH Clinical Trials: A phase II study to evaluate prophylactic treatment of dacomitinib-induced dermatologic adverse events in EGFR-mutated advanced non-small cell lung cancer
• Description: Difluprednate is a synthetic glucocorticoid that potently activates the glucocorticoid receptor (Ki = 78 pM). In vivo, ocular administration of difluprednate (0.05% w/v) increases intraocular pressure in sheep. Formulations containing difluprednate have been used to treat diabetic macular edema and inflammation following cataract surgery.
• Uses: Difluprednate-d3 is the isotope labeled form of Difluprednate (D445925), a corticosteroid (derivative of prednisolone), approved for the treatment of post-operative ocular inflammation. A corticosteroid (derivative of prednisolone), approved for the treatment of post-operative ocular inflammation.
• Therapeutic Function: Antiinflammatory

Technology Process of Difluprednate

There total 2 articles about Difluprednate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 6α,9α-Difluor-prednisolon-17-butyrat-21-acetat (23674-86-4)

Guidance literature:

6α,9α-Difluor-prednisolon-21-dihydrogenphosphat, 1) Buttersaeureanhydrid, 2) Acetatpuffer;

Reference yield:

→ 6α,9α-Difluoro-prednisolone-17-butyrate-21-acetate (23674-86-4)

Guidance literature:

6α,9α-Difluoro-prednisolone-17-Butyrate, Py., acetic anhydride;