3-Pyridinecarboxamide, 2-fluoro-N-phenyl-

Base Information

• Chemical Name: 3-Pyridinecarboxamide, 2-fluoro-N-phenyl-
• CAS No.: 920986-88-5
• Molecular Formula: C12H9FN2O
• Molecular Weight: 216.215
• Mol file: 920986-88-5.mol

Synonyms:

Chemical Property of 3-Pyridinecarboxamide, 2-fluoro-N-phenyl-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Pyridinecarboxamide, 2-fluoro-N-phenyl-

There total 1 articles about 3-Pyridinecarboxamide, 2-fluoro-N-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-fluoronicotinic acid (393-55-5) + aniline (62-53-3) → 2-fluoro-N-phenylnicotinamide (920986-88-5)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; at 20 ℃; for 16h;

DOI:10.1055/s-0030-1258302

Reference yield: 65.0%

2-fluoro-N-phenylnicotinamide (920986-88-5) + phenylpropynoic acid ethyl ester (2216-94-6) → ethyl 5-oxo-6,7-diphenyl-5,6-dihydro-1,6-naphthyridine-8-carboxylate (1285712-17-5)

Guidance literature:

2-fluoro-N-phenylnicotinamide; With sodium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide; at 0 ℃; for 0.5h; Inert atmosphere;

phenylpropynoic acid ethyl ester; In tetrahydrofuran; N,N-dimethyl-formamide; at 200 ℃; for 4h; Microwave irradiation; Inert atmosphere;

DOI:10.1055/s-0030-1258302

Reference yield: 53.0%

2-fluoro-N-phenylnicotinamide (920986-88-5) + ethyl 2-hexynoate (16205-90-6) → tert-butyl 7-methyl-5-oxo-6-phenyl-5,6-dihydro-1,6-naphthyridine-8-carboxylate (1285712-27-7)

Guidance literature:

2-fluoro-N-phenylnicotinamide; With sodium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide; at 0 ℃; for 0.5h; Inert atmosphere;

ethyl 2-hexynoate; In tetrahydrofuran; N,N-dimethyl-formamide; at 200 ℃; for 4h; Microwave irradiation; Inert atmosphere;

DOI:10.1055/s-0030-1258302

upstream raw materials:

2-fluoronicotinic acid

aniline

Downstream raw materials:

C₁₂H₉FN₂S

tert-butyl 7-methyl-5-oxo-6-phenyl-5,6-dihydro-1,6-naphthyridine-8-carboxylate

ethyl 7-methyl-5-oxo-6-phenyl-5,6-dihydro-1,6-naphthyridine-8-carboxylate

ethyl 5-oxo-6,7-diphenyl-5,6-dihydro-1,6-naphthyridine-8-carboxylate

Refernces

• 1、 Burke, Michael J.,Trantow, Brian M.. "An efficient route to 3-aminoindazoles and 3-amino-7-azaindazoles". . p. 4579 - 4581. Retrieved 2008/09/21.