3-Hexanol, 2,4,5-trifluoro-1,6-bis(phenylmethoxy)-, (2R,3R,4R,5R)-

Base Information

Chemical Name:3-Hexanol, 2,4,5-trifluoro-1,6-bis(phenylmethoxy)-, (2R,3R,4R,5R)-
CAS No.:921038-80-4
Molecular Formula:C20H23F3O3
Molecular Weight:368.396
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-Hexanol, 2,4,5-trifluoro-1,6-bis(phenylmethoxy)-, (2R,3R,4R,5R)-

Chemical Property:

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Technology Process of 3-Hexanol, 2,4,5-trifluoro-1,6-bis(phenylmethoxy)-, (2R,3R,4R,5R)-

There total 5 articles about 3-Hexanol, 2,4,5-trifluoro-1,6-bis(phenylmethoxy)-, (2R,3R,4R,5R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 921038-79-1
4,5-bis-(2-benzyloxy-1-fluoroethyl)-[1,3,2]dioxathiolane 2,2-dioxide

: 921038-80-4
(2R,3R,4R,5R)-1,6-bis-benzyloxy-2,4,5-trifluorohexan-3-ol

Guidance literature:: 4,5-bis-(2-benzyloxy-1-fluoroethyl)-[1,3,2]dioxathiolane 2,2-dioxide; With tetrabutyl ammonium fluoride; In tetrahydrofuran; acetonitrile; at 0 - 20 ℃; for 4h;

With sulfuric acid; In tetrahydrofuran; at 20 ℃; for 48h;
DOI:10.1021/ja066188p

Reference yield:

: 4,5-bis-(2-benzyloxy-1-fluoro-ethyl)-[1,3,2]dioxathiolane 2-oxide

: 921038-80-4
(2R,3R,4R,5R)-1,6-bis-benzyloxy-2,4,5-trifluorohexan-3-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: 0.491 g / NaIO₄ / RuCl₃*H₂O / acetonitrile; H₂O / 3 h / 0 °C

2.1: tetrabutylammonium fluoride / acetonitrile; tetrahydrofuran / 4 h / 0 - 20 °C

2.2: 62 percent / aq. H₂SO₄ / tetrahydrofuran / 48 h / 20 °C

With sodium periodate; tetrabutyl ammonium fluoride; ruthenium trichloride; In tetrahydrofuran; water; acetonitrile;
DOI:10.1021/ja066188p

Reference yield:

: 638538-15-5
(S)-(((2-fluorobut-3-en-1-yl)oxy)methyl)benzene

: 921038-80-4
(2R,3R,4R,5R)-1,6-bis-benzyloxy-2,4,5-trifluorohexan-3-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: Grubss second generation catalyst / CH₂Cl₂ / 6 h / Heating

2.1: 60 percent / aq. KMnO₄; MgSO₄ / ethanol; CH₂Cl₂ / 20 h / -10 °C

3.1: SOCl₂; pyridine / CH₂Cl₂ / 2 h / 0 °C

4.1: 0.491 g / NaIO₄ / RuCl₃*H₂O / acetonitrile; H₂O / 3 h / 0 °C

5.1: tetrabutylammonium fluoride / acetonitrile; tetrahydrofuran / 4 h / 0 - 20 °C

5.2: 62 percent / aq. H₂SO₄ / tetrahydrofuran / 48 h / 20 °C

With pyridine; potassium permanganate; sodium periodate; thionyl chloride; tetrabutyl ammonium fluoride; magnesium sulfate; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; ruthenium trichloride; In tetrahydrofuran; ethanol; dichloromethane; water; acetonitrile;
DOI:10.1021/ja066188p