Phosphonium, [2-[9-[(1,1-dimethylethoxy)carbonyl]-2-oxo-5-[(2,2,2-trichloroethoxy)carb onyl]-1,5,9-triazacyclotridec-4-yl]ethyl]triphenyl-, bromide

Base Information

• Chemical Name: Phosphonium, [2-[9-[(1,1-dimethylethoxy)carbonyl]-2-oxo-5-[(2,2,2-trichloroethoxy)carb onyl]-1,5,9-triazacyclotridec-4-yl]ethyl]triphenyl-, bromide
• CAS No.: 92118-56-4
• Molecular Formula: Br*C₃₈H₄₈Cl₃N₃O₅P
• Molecular Weight: 844.053
• Mol file: 92118-56-4.mol

Synonyms:

Chemical Property of Phosphonium, [2-[9-[(1,1-dimethylethoxy)carbonyl]-2-oxo-5-[(2,2,2-trichloroethoxy)carb onyl]-1,5,9-triazacyclotridec-4-yl]ethyl]triphenyl-, bromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Phosphonium, [2-[9-[(1,1-dimethylethoxy)carbonyl]-2-oxo-5-[(2,2,2-trichloroethoxy)carb onyl]-1,5,9-triazacyclotridec-4-yl]ethyl]triphenyl-, bromide

There total 7 articles about Phosphonium, [2-[9-[(1,1-dimethylethoxy)carbonyl]-2-oxo-5-[(2,2,2-trichloroethoxy)carb onyl]-1,5,9-triazacyclotridec-4-yl]ethyl]triphenyl-, bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(Z)-4-Methoxy-2,3,6,7,8,9-hexahydro-[1,5]diazonine-1-carboxylic acid tert-butyl ester (92118-50-8) → {2-[9-tert-Butoxycarbonyl-2-oxo-5-(2,2,2-trichloro-ethoxycarbonyl)-1,5,9-triaza-cyclotridec-4-yl]-ethyl}-triphenyl-phosphonium; bromide (92118-56-4)

Guidance literature:

Multi-step reaction with 6 steps

1: 65 percent / 1,3,5-trimethyl-benzene / 145 °C

2: 90 percent / NaBH₃(CN) / acetic acid

3: 90 percent / DMAP

4: 95 percent / NaOCH₃

5: triphenylphosphite dibromide

6: Heating

With dmap; triphenylphosphite dibromide; sodium methylate; sodium cyanoborohydride; In acetic acid; 1,3,5-trimethyl-benzene;

DOI:10.1016/S0040-4039(01)80263-X

Reference yield:

2-(2-Acetoxy-ethyl)-4-oxo-3,4,5,6,7,8,10,11-octahydro-2H-1,4a,9-triaza-benzocyclononene-9-carboxylic acid tert-butyl ester (98262-73-8) → {2-[9-tert-Butoxycarbonyl-2-oxo-5-(2,2,2-trichloro-ethoxycarbonyl)-1,5,9-triaza-cyclotridec-4-yl]-ethyl}-triphenyl-phosphonium; bromide (92118-56-4)

Guidance literature:

Multi-step reaction with 5 steps

1: 90 percent / NaBH₃(CN) / acetic acid

2: 90 percent / DMAP

3: 95 percent / NaOCH₃

4: triphenylphosphite dibromide

5: Heating

With dmap; triphenylphosphite dibromide; sodium methylate; sodium cyanoborohydride; In acetic acid;

DOI:10.1016/S0040-4039(01)80263-X

Reference yield:

4-(2-acetoxyethyl)-2-azetidinone (64066-60-0) → {2-[9-tert-Butoxycarbonyl-2-oxo-5-(2,2,2-trichloro-ethoxycarbonyl)-1,5,9-triaza-cyclotridec-4-yl]-ethyl}-triphenyl-phosphonium; bromide (92118-56-4)

Guidance literature:

Multi-step reaction with 6 steps

1: 65 percent / 1,3,5-trimethyl-benzene / 145 °C

2: 90 percent / NaBH₃(CN) / acetic acid

3: 90 percent / DMAP

4: 95 percent / NaOCH₃

5: triphenylphosphite dibromide

6: Heating

With dmap; triphenylphosphite dibromide; sodium methylate; sodium cyanoborohydride; In acetic acid; 1,3,5-trimethyl-benzene;

DOI:10.1016/S0040-4039(01)80263-X

upstream raw materials:

6-(2-Bromo-ethyl)-8-oxo-1,5,9-triaza-cyclotridecane-1,5-dicarboxylic acid 1-tert-butyl ester 5-(2,2,2-trichloro-ethyl) ester

triphenylphosphine

(Z)-4-Methoxy-2,3,6,7,8,9-hexahydro-[1,5]diazonine-1-carboxylic acid tert-butyl ester

7-tert-butoxycarbonyl-12-(2-acetoxyethyl)-2,7,11-triazatridecanone