4H-1,4-Benzoxazine-4-carboxylic acid, 6,8-dichloro-2,3-dihydro-7-methyl-2-oxo-3-(phenylmethyl)-, 9H-fluoren-9-ylmethyl ester, (3R)-

Base Information

Chemical Name:4H-1,4-Benzoxazine-4-carboxylic acid, 6,8-dichloro-2,3-dihydro-7-methyl-2-oxo-3-(phenylmethyl)-, 9H-fluoren-9-ylmethyl ester, (3R)-
CAS No.:921198-84-7
Molecular Formula:C31H23Cl2NO4
Molecular Weight:544.434
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4H-1,4-Benzoxazine-4-carboxylic acid, 6,8-dichloro-2,3-dihydro-7-methyl-2-oxo-3-(phenylmethyl)-, 9H-fluoren-9-ylmethyl ester, (3R)-

Chemical Property:

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Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4H-1,4-Benzoxazine-4-carboxylic acid, 6,8-dichloro-2,3-dihydro-7-methyl-2-oxo-3-(phenylmethyl)-, 9H-fluoren-9-ylmethyl ester, (3R)-

There total 3 articles about 4H-1,4-Benzoxazine-4-carboxylic acid, 6,8-dichloro-2,3-dihydro-7-methyl-2-oxo-3-(phenylmethyl)-, 9H-fluoren-9-ylmethyl ester, (3R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: C₂₂H₁₅Cl₂NO₃

: 645-45-4
hydrocinnamic acid chloride

: 921198-84-7
(R)-(9H-fluoren-9-yl)methyl 3-benzyl-6,8-dichloro-7-methyl-2-oxo-2,3-dihydrobenzo[b][1,4]oxazine-4-carboxylate

Guidance literature:: With benzoylquinidine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at -78 ℃;
DOI:10.2533/chimia.2007.240

Reference yield: 62.0%

: C₂₂H₁₅O₃Cl₂N

: 645-45-4
hydrocinnamic acid chloride

: 921198-84-7
(R)-(9H-fluoren-9-yl)methyl 3-benzyl-6,8-dichloro-7-methyl-2-oxo-2,3-dihydrobenzo[b][1,4]oxazine-4-carboxylate

Guidance literature:: With benzoylquinidine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at -78 ℃; for 4h;
DOI:10.1002/anie.200602801

Reference yield:

: 921198-87-0
9-fluorenylmethyl 3,5-dichloro-2-hydroxy-4-methylphenylcarbamate

: 921198-84-7
(R)-(9H-fluoren-9-yl)methyl 3-benzyl-6,8-dichloro-7-methyl-2-oxo-2,3-dihydrobenzo[b][1,4]oxazine-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: Pb(OAc)4 / tetrahydrofuran / 0.08 h / -78 °C

2: 62 percent / N,N-diisopropylethylamine; benzoylquinidine / tetrahydrofuran / 4 h / -78 °C

With lead(IV) acetate; benzoylquinidine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;
DOI:10.1002/anie.200602801