D-Proline, 5-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-4-(phenylmethoxy)-, ethyl ester, (4S,5R)-

Base Information

Chemical Name:D-Proline, 5-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-4-(phenylmethoxy)-, ethyl ester, (4S,5R)-
CAS No.:921201-54-9
Molecular Formula:C₂₁H₃₅NO₄Si
Molecular Weight:393.599
Hs Code.:

Synonyms:

Suppliers and Price of D-Proline, 5-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-4-(phenylmethoxy)-, ethyl ester, (4S,5R)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of D-Proline, 5-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-4-(phenylmethoxy)-, ethyl ester, (4S,5R)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of D-Proline, 5-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-4-(phenylmethoxy)-, ethyl ester, (4S,5R)-

There total 7 articles about D-Proline, 5-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-4-(phenylmethoxy)-, ethyl ester, (4S,5R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-benzyloxy-2-tert-butoxycarbonylamino-6-(tert-butyl-dimethyl-silanyloxy)-5-methanesulfonyl-hexanoic acid ethyl ester

: 921201-54-9
(2R,4S,5R)-ethyl-4-(benzyloxy)-5-(tert-butyl dimethyl silyloxy methyl)pyrrolidine-2-carboxylate

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃;
DOI:10.1016/j.tetasy.2006.10.033

Reference yield:

: 921201-39-0
tert-butyl (S)-1-(ethoxycarbonyl)-3-(benzyloxy)-3-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)prop-1-enyl carbamate

: 921201-54-9
(2R,4S,5R)-ethyl-4-(benzyloxy)-5-(tert-butyl dimethyl silyloxy methyl)pyrrolidine-2-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: Na₂CO₃; hydrogen / palladium on carbon / ethyl acetate / 3 h / atmospheric pressure

2: pyridinium para-toluenesulfonate / ethanol / Heating

3: imidazole / CH₂Cl₂ / 20 °C

4: DIPEA; methanesulfonyl chloride / CH₂Cl₂ / 20 °C

5: trifluoroacetic acid / CH₂Cl₂ / 20 °C

With 1H-imidazole; hydrogen; pyridinium p-toluenesulfonate; sodium carbonate; methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium on activated charcoal; In ethanol; dichloromethane; ethyl acetate;
DOI:10.1016/j.tetasy.2006.10.033

Reference yield:

: 100906-42-1
2-O-benzyl-3,4-O-isopropylidene-L-threose

: 921201-54-9
(2R,4S,5R)-ethyl-4-(benzyloxy)-5-(tert-butyl dimethyl silyloxy methyl)pyrrolidine-2-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium tert-butoxide / CH₂Cl₂ / 0.5 h / cooling

1.2: CH₂Cl₂ / 5 h / 20 °C

2.1: Na₂CO₃; hydrogen / palladium on carbon / ethyl acetate / 3 h / atmospheric pressure

3.1: pyridinium para-toluenesulfonate / ethanol / Heating

4.1: imidazole / CH₂Cl₂ / 20 °C

5.1: DIPEA; methanesulfonyl chloride / CH₂Cl₂ / 20 °C

6.1: trifluoroacetic acid / CH₂Cl₂ / 20 °C

With 1H-imidazole; potassium tert-butylate; hydrogen; pyridinium p-toluenesulfonate; sodium carbonate; methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium on activated charcoal; In ethanol; dichloromethane; ethyl acetate; 1.2: Wittig-Horner reaction;
DOI:10.1016/j.tetasy.2006.10.033