(2S,3R)-1-benzyl-2-(hydroxymethyl)pyrrolidin-3-ol

Base Information

Chemical Name:(2S,3R)-1-benzyl-2-(hydroxymethyl)pyrrolidin-3-ol
CAS No.:921202-64-4
Molecular Formula:C12H17NO2
Molecular Weight:207.272
Hs Code.:
DSSTox Substance ID:DTXSID90580088
Wikidata:Q82470834

Synonyms:(2S,3R)-1-benzyl-2-(hydroxymethyl)pyrrolidin-3-ol;921202-64-4;SCHEMBL18922664;DTXSID90580088

Suppliers and Price of (2S,3R)-1-benzyl-2-(hydroxymethyl)pyrrolidin-3-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 0 raw suppliers

Chemical Property of (2S,3R)-1-benzyl-2-(hydroxymethyl)pyrrolidin-3-ol

Chemical Property:

Boiling Point:357.6±27.0 °C(Predicted)
PSA：43.70000
Density:1.193±0.06 g/cm3(Predicted)
LogP:0.55200
XLogP3:1.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:207.125928785
Heavy Atom Count:15
Complexity:192

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(C(C1O)CO)CC2=CC=CC=C2
Isomeric SMILES:C1CN([C@H]([C@@H]1O)CO)CC2=CC=CC=C2

Technology Process of (2S,3R)-1-benzyl-2-(hydroxymethyl)pyrrolidin-3-ol

There total 2 articles about (2S,3R)-1-benzyl-2-(hydroxymethyl)pyrrolidin-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 921202-52-0
(2S,3R)-1-benzyl-2-vinylpyrrolidin-3-ol

: 921202-64-4
(2S,3R)-1-benzyl-2-(hydroxymethyl)pyrrolidin-3-ol

: 101385-90-4,101930-07-8,101979-03-7,775-15-5
(R)-N-benzyl-3-hydroxypyrrolidine

Guidance literature:: (2S,3R)-1-benzyl-2-vinylpyrrolidin-3-ol; With hydrogenchloride; In methanol; at 0 ℃; for 0.5h; Inert atmosphere;

With ozone; In methanol; at -78 ℃;

With sodium tetrahydroborate; In methanol; at -78 - -10 ℃; Inert atmosphere;
DOI:10.1002/ejoc.200900100

Reference yield:

: C₁₂H₁₅NO₂

: 921202-64-4
(2S,3R)-1-benzyl-2-(hydroxymethyl)pyrrolidin-3-ol

Guidance literature:: With sodium tetrahydroborate; In methanol; at -78 - -10 ℃;
DOI:10.1039/b613460b

Reference yield: 100.0%

: 921202-64-4
(2S,3R)-1-benzyl-2-(hydroxymethyl)pyrrolidin-3-ol

: 198705-78-1,350592-84-6
(S,R)-3-hydroxy-2-hydroxymethylpyrrolidine

Guidance literature:: With hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol; under 5250.53 - 6000.6 Torr;
DOI:10.1039/b613460b