2,4-Heptadienoic acid, 7-[4-(dimethylamino)phenyl]-7-methoxy-4,6-dimethyl-, (2E,4E,6R)-

Base Information

Chemical Name:2,4-Heptadienoic acid, 7-[4-(dimethylamino)phenyl]-7-methoxy-4,6-dimethyl-, (2E,4E,6R)-
CAS No.:921213-02-7
Molecular Formula:C18H25NO3
Molecular Weight:303.401
Hs Code.:

Synonyms:

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Chemical Property of 2,4-Heptadienoic acid, 7-[4-(dimethylamino)phenyl]-7-methoxy-4,6-dimethyl-, (2E,4E,6R)-

Chemical Property:

Purity/Quality:

Safty Information:

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Hazard Codes:

MSDS Files:: SDS file from LookChem

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Technology Process of 2,4-Heptadienoic acid, 7-[4-(dimethylamino)phenyl]-7-methoxy-4,6-dimethyl-, (2E,4E,6R)-

There total 5 articles about 2,4-Heptadienoic acid, 7-[4-(dimethylamino)phenyl]-7-methoxy-4,6-dimethyl-, (2E,4E,6R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: methyl (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-7-methoxy-4,6-dimethyl-2,4-heptadienoate

: 921213-02-7
(2E,4E,6R)-7-[4-(dimethylamino)phenyl]-7-methoxy-4,6-dimethyl-2,4-heptadienoic acid

Guidance literature:: methyl (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-7-methoxy-4,6-dimethyl-2,4-heptadienoate; With lithium hydroxide;

In water; pH=4 - 7; Aqueous phosphate buffer;

Reference yield:

: 100-10-7
4-dimethylamino-benzaldehyde

: 921213-02-7
(2E,4E,6R)-7-[4-(dimethylamino)phenyl]-7-methoxy-4,6-dimethyl-2,4-heptadienoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: indium iodide / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N,N,N,N,N-hexamethylphosphoric triamide; tetrahydrofuran / 1 h / 0 °C

2.1: trifluoroacetic acid / 48 h / 25 °C

3.1: 2,2,6,6-tetramethylpiperidinyl-lithium / tetrahydrofuran / 0.5 h / -78 °C

3.2: 6.5 h / -78 - 0 °C

4.1: (-)-Ipc₂BH / tetrahydrofuran / 2 h / 0 °C

4.2: 1 h / 0 - 20 °C

5.1: lithium hydroxide / methanol / 24 h / 45 °C

5.2: pH 4

With indium iodide; 2,2,6,6-tetramethylpiperidinyl-lithium; trifluoroacetic acid; lithium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; 1.1: Marshall Coupling / 4.2: Suzuki-Miyaura Coupling;

Reference yield:

: 1334686-42-8
4-[(2R)-1-methoxy-2-methylbut-3-yn-1-yl]-N,N-dimethylaniline

: 921213-02-7
(2E,4E,6R)-7-[4-(dimethylamino)phenyl]-7-methoxy-4,6-dimethyl-2,4-heptadienoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: 2,2,6,6-tetramethylpiperidinyl-lithium / tetrahydrofuran / 0.5 h / -78 °C

1.2: 6.5 h / -78 - 0 °C

2.1: (-)-Ipc₂BH / tetrahydrofuran / 2 h / 0 °C

2.2: 1 h / 0 - 20 °C

3.1: lithium hydroxide / methanol / 24 h / 45 °C

3.2: pH 4

With 2,2,6,6-tetramethylpiperidinyl-lithium; lithium hydroxide; In tetrahydrofuran; methanol; 2.2: Suzuki-Miyaura Coupling;