Boc-cycloleucine

Base Information

• Chemical Name: Boc-cycloleucine
• CAS No.: 35264-09-6
• Molecular Formula: C11H19NO4
• Molecular Weight: 229.276
• Hs Code.: 29242990
• DSSTox Substance ID: DTXSID00370417
• Nikkaji Number: J733.361G
• Wikidata: Q72448023
• ChEMBL ID: CHEMBL1222332
• Mol file: 35264-09-6.mol

Synonyms:Boc-cycloleucine;35264-09-6;1-(Boc-amino)cyclopentanecarboxylic acid;1-((tert-Butoxycarbonyl)amino)cyclopentanecarboxylic acid;Boc-1-aminocyclopentane-1-carboxylic acid;1-(tert-Butoxycarbonylamino)cyclopentanecarboxylic Acid;MFCD01076126;N-Boc-cycloleucine;1-tert-Butoxycarbonylamino-cyclopentanecarboxylic acid;1-[(2-methylpropan-2-yl)oxycarbonylamino]cyclopentane-1-carboxylic Acid;Boc-Cyclolencine;1-{[(tert-butoxy)carbonyl]amino}cyclopentane-1-carboxylic acid;Cyclopentanecarboxylic acid, 1-[[(1,1-dimethylethoxy)carbonyl]amino]-;1-N-Boc-Aminocyclopentanecarboxylic acid;1-[(tert-butoxycarbonyl)amino]cyclopentanecarboxylic acid;1-[(tert-butoxycarbonyl)amino)cyclopentanecarboxylic acid;Boc-NH(1)cPen-OH;SCHEMBL76966;CHEMBL1222332;DTXSID00370417;YBZCSKVLXBOFSL-UHFFFAOYSA-N;1-((tert-butoxycarbonyl)amino)cyclopentane-1-carboxylic acid;FD1034;AKOS005146315;AC-5712;Boc-1-aminocyclopentane-1-carboxy acid;CS-W007993;SB16137;DS-14512;SY002603;1-Boc-1-Amino-1-cyclopentanecarboxylic acid;AM20090556;B3831;FT-0605811;EN300-49670;N-[(1,1-dimethylethoxy)carbonyl]cycloleucine;N-Boc-1-amino-1-cyclopentane carboxylic acid;tert-butoxycarbonylaminocyclopentanecarboxylic acid;1-((tert-Butoxycarbonyl)amino)cyclopentanecarboxylicacid;1-(tert-butoxycarbonylamino)-cyclopentanecarboxylic acid;1-tert-butoxycarbonylamino-1-cyclopentanecarboxylic acid;1-tert-butoxycarbonylaminocyclopentane-1-carboxylic acid;Z385440222;1-(Boc-amino)cyclopentanecarboxylic acid, >=98.0% (TLC);1-[N-[(1,1-dimethylethoxy)carbonyl]amino]cyclopentanecarboxylic acid

Chemical Property of Boc-cycloleucine

Chemical Property:

• Appearance/Colour: white to off-white crystalline powder
• Vapor Pressure: 1.04E-06mmHg at 25°C
• Melting Point: 130-135 °C
• Boiling Point: 376.605 °C at 760 mmHg
• PKA: 4.14±0.20(Predicted)
• Flash Point: 181.565 °C
• PSA: 75.63000
• Density: 1.157 g/cm³
• LogP: 2.29940
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility.: soluble in Methanol
• Water Solubility.: Soluble in hot water
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 229.13140809
• Heavy Atom Count: 16
• Complexity: 287

Purity/Quality:

99% ^*data from raw suppliers

Boc-cycloleucine ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)NC1(CCCC1)C(=O)O

Technology Process of Boc-cycloleucine

There total 11 articles about Boc-cycloleucine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

di-tert-butyl dicarbonate (24424-99-5) + 1-amino-1-cyclopentanecarboxylic acid (52-52-8) → 1-(tert-butoxycarbonylamino)cyclopentanecarboxylic acid (35264-09-6)

Guidance literature:

With sodium hydroxide; In water; acetone; Inert atmosphere;

DOI:10.1002/chem.201100113

Reference yield: 59.0%

di-tert-butyl dicarbonate (24424-99-5) + pentahydrated tetramethylammonium hydroxide → 1-(tert-butoxycarbonylamino)cyclopentanecarboxylic acid (35264-09-6)

Guidance literature:

In water; ethyl acetate; acetonitrile;

Reference yield: 57.0%

di-tert-butyl dicarbonate (24424-99-5) → 1-(tert-butoxycarbonylamino)cyclopentanecarboxylic acid (35264-09-6)

Guidance literature:

1-amino-1-cyclopentanecarboxylic acid; With tetramethyl ammoniumhydroxide; In acetonitrile; at 20 ℃;

di-tert-butyl dicarbonate; In acetonitrile; for 96h;

With citric acid; In water; pH=3 - 4;

upstream raw materials:

N-(tert-butyloxycarbonyl) azide

1-amino-1-cyclopentanecarboxylic acid

di-tert-butyl dicarbonate

2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile

Downstream raw materials:

(S)-2-[(1-tert-Butoxycarbonylamino-cyclopentanecarbonyl)-amino]-3-(4-hydroxy-phenyl)-propionic acid methyl ester

(S)-2-[(1-tert-Butoxycarbonylamino-cyclopentanecarbonyl)-amino]-3-(4-methoxy-phenyl)-propionic acid methyl ester

(S)-2-[(1-tert-Butoxycarbonylamino-cyclopentanecarbonyl)-amino]-4-phenyl-butyric acid ethyl ester

(S)-3-Biphenyl-4-yl-2-[(1-tert-butoxycarbonylamino-cyclopentanecarbonyl)-amino]-propionic acid methyl ester