1H-Pyrazole-3-carboxamide, 4-cyano-1-(2,4-dichlorophenyl)-5-(4-hydroxyphenyl)-N-1-piperidinyl-

Base Information

• Chemical Name: 1H-Pyrazole-3-carboxamide, 4-cyano-1-(2,4-dichlorophenyl)-5-(4-hydroxyphenyl)-N-1-piperidinyl-
• CAS No.: 921590-81-0
• Molecular Formula: C22H19Cl2N5O2
• Molecular Weight: 456.331

Synonyms:4-cyano-1-(2,4-dichlorophenyl)-5-(4-hydroxyphenyl)-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide;4-cyano-1-(2,4-dichlorophenyl)-5-(4-hydroxyphenyl)-N-piperidin-1-yl-1H-pyrazole-3-carboxamide;4-cyano-1-(2,4-dichloro-phenyl)-5-(4-hydroxy-phenyl)-1H-pyrazole-3-carboxylic acid piperidin-1-ylamide;

Chemical Property of 1H-Pyrazole-3-carboxamide, 4-cyano-1-(2,4-dichlorophenyl)-5-(4-hydroxyphenyl)-N-1-piperidinyl-

Chemical Property:

• PSA: 94.18000
• LogP: 4.88288

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Pyrazole-3-carboxamide, 4-cyano-1-(2,4-dichlorophenyl)-5-(4-hydroxyphenyl)-N-1-piperidinyl-

There total 12 articles about 1H-Pyrazole-3-carboxamide, 4-cyano-1-(2,4-dichlorophenyl)-5-(4-hydroxyphenyl)-N-1-piperidinyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

5-(4-(allyloxy)phenyl)-1-(2,4-chlorophenyl)-4-cyano-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide (951790-64-0) → 1-(2,4-dichlorophenyl)-4-cyano-5-(4-hydroxyphenyl)-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide (921590-81-0)

Guidance literature:

With phenylsilane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1002/jlcr.1125

Reference yield:

5-[4-(benzyloxy)phenyl]-4-cyano-1-(2,4-dichlorophenyl)-N-piperidin-1-yl-1H-pyrazole-3-carboxamide (921590-80-9) → 1-(2,4-dichlorophenyl)-4-cyano-5-(4-hydroxyphenyl)-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide (921590-81-0)

Guidance literature:

With dimethylsulfide; boron trifluoride diethyl etherate; In dichloromethane; at 20 ℃; for 47h;

Reference yield:

JHU75528 → 1-(2,4-dichlorophenyl)-4-cyano-5-(4-hydroxyphenyl)-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide (921590-81-0)

Guidance literature:

With lithium bromide; In N,N-dimethyl-formamide; for 44h; Inert atmosphere; Reflux;

DOI:10.1016/j.bmcl.2012.04.030

upstream raw materials:

5-(4-(allyloxy)phenyl)-1-(2,4-chlorophenyl)-4-cyano-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide

5-(4-(allyloxy)phenyl)-1-(2,4-dichlorophenyl)-4-cyano-1H-pyrazole-3-carboxylic acid

ethyl 5-(4-(allyloxy)phenyl)-1-(2,4-dichlorophenyl)-4-cyano-1H-pyrazole-3-carboxylate

Ethyl 4-hydroxybenzoate

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