1H-Pyrazole-3-carboxamide, 1-(2,4-dichlorophenyl)-N-(4-hydroxy-1-piperidinyl)-4-methyl-5-[4-(phenyl methoxy)phenyl]-

Base Information

• Chemical Name: 1H-Pyrazole-3-carboxamide, 1-(2,4-dichlorophenyl)-N-(4-hydroxy-1-piperidinyl)-4-methyl-5-[4-(phenyl methoxy)phenyl]-
• CAS No.: 921590-91-2
• Molecular Formula: C29H28Cl2N4O3
• Molecular Weight: 551.472
• Mol file: 921590-91-2.mol

Synonyms:

Chemical Property of 1H-Pyrazole-3-carboxamide, 1-(2,4-dichlorophenyl)-N-(4-hydroxy-1-piperidinyl)-4-methyl-5-[4-(phenyl methoxy)phenyl]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Pyrazole-3-carboxamide, 1-(2,4-dichlorophenyl)-N-(4-hydroxy-1-piperidinyl)-4-methyl-5-[4-(phenyl methoxy)phenyl]-

There total 1 articles about 1H-Pyrazole-3-carboxamide, 1-(2,4-dichlorophenyl)-N-(4-hydroxy-1-piperidinyl)-4-methyl-5-[4-(phenyl methoxy)phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-aminopiperidin-4-ol (79414-82-7) + C24H17Cl3N2O2 → 5-(4-benzyloxyphenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid (4-hydroxypiperidin-1-yl)amide (921590-91-2)

Guidance literature:

1-aminopiperidin-4-ol; C₂₄H₁₇Cl₃N₂O₂; With triethylamine; In tetrahydrofuran; dichloromethane; at -30 - 20 ℃;

With sodium hydroxide; In tetrahydrofuran; dichloromethane; water;

Reference yield: 76.0%

5-(4-benzyloxyphenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid (4-hydroxypiperidin-1-yl)amide (921590-91-2) → 1-(2,4-dichlorophenyl)-5-(4-hydroxyphenyl)-4-methyl-1H-pyrazole-3-carboxylic acid (4-hydroxypiperidin-1-yl)amide

Guidance literature:

With dimethylsulfide; boron trifluoride diethyl etherate; In dichloromethane; at 20 ℃; for 144h;

upstream raw materials:

1-aminopiperidin-4-ol