1,3-Dioxolane, 4-[(1E)-4-[(2S,4S,5R)-4-(dimethylphenylsilyl)tetrahydro-5-[(1S,2R,3R)- 2-[(4-methoxyphenyl)methoxy]-3-methyl-1-[(triethylsilyl)oxy]-5-hexyn-1-yl] -2-furanyl]-1-buten-1-yl]-5-ethenyl-2,2-dimethyl-, (4R,5R)-

Base Information

Chemical Name:1,3-Dioxolane, 4-[(1E)-4-[(2S,4S,5R)-4-(dimethylphenylsilyl)tetrahydro-5-[(1S,2R,3R)- 2-[(4-methoxyphenyl)methoxy]-3-methyl-1-[(triethylsilyl)oxy]-5-hexyn-1-yl] -2-furanyl]-1-buten-1-yl]-5-ethenyl-2,2-dimethyl-, (4R,5R)-
CAS No.:921763-52-2
Molecular Formula:C44H66O6Si2
Molecular Weight:747.175
Hs Code.:

1,3-Dioxolane,
4-[(1E)-4-[(2S,4S,5R)-4-(dimethylphenylsilyl)tetrahydro-5-[(1S,2R,3R)-
2-[(4-methoxyphenyl)methoxy]-3-methyl-1-[(triethylsilyl)oxy]-5-hexyn-1-yl]
-2-furanyl]-1-buten-1-yl]-5-ethenyl-2,2-dimethyl-, (4R,5R)-

Synonyms:

Suppliers and Price of 1,3-Dioxolane, 4-[(1E)-4-[(2S,4S,5R)-4-(dimethylphenylsilyl)tetrahydro-5-[(1S,2R,3R)- 2-[(4-methoxyphenyl)methoxy]-3-methyl-1-[(triethylsilyl)oxy]-5-hexyn-1-yl] -2-furanyl]-1-buten-1-yl]-5-ethenyl-2,2-dimethyl-, (4R,5R)-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1,3-Dioxolane, 4-[(1E)-4-[(2S,4S,5R)-4-(dimethylphenylsilyl)tetrahydro-5-[(1S,2R,3R)- 2-[(4-methoxyphenyl)methoxy]-3-methyl-1-[(triethylsilyl)oxy]-5-hexyn-1-yl] -2-furanyl]-1-buten-1-yl]-5-ethenyl-2,2-dimethyl-, (4R,5R)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1,3-Dioxolane, 4-[(1E)-4-[(2S,4S,5R)-4-(dimethylphenylsilyl)tetrahydro-5-[(1S,2R,3R)- 2-[(4-methoxyphenyl)methoxy]-3-methyl-1-[(triethylsilyl)oxy]-5-hexyn-1-yl] -2-furanyl]-1-buten-1-yl]-5-ethenyl-2,2-dimethyl-, (4R,5R)-

There total 14 articles about 1,3-Dioxolane, 4-[(1E)-4-[(2S,4S,5R)-4-(dimethylphenylsilyl)tetrahydro-5-[(1S,2R,3R)- 2-[(4-methoxyphenyl)methoxy]-3-methyl-1-[(triethylsilyl)oxy]-5-hexyn-1-yl] -2-furanyl]-1-buten-1-yl]-5-ethenyl-2,2-dimethyl-, (4R,5R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 921763-53-3
(E)-5-((4R,5R)-2,2-dimethyl-5-vinyl-[1,3]dioxolan-4-yl)-pent-4-enal

: 921763-54-4
1-[(1R,2S,3R)-3-(dimethyl-phenyl-silanyl)-1-((R)-1-methyl-but-3-ynyl)-2-triethylsilanyloxypent-4-enyloxymethyl]-4-methoxy-benzene

: 921763-52-2
(4R,5R)-4-((E)-4-{(2S,4S,5R)-4-(dimethyl-phenyl-silanyl)-5-[(1S,2R,3R)-2-(4-methoxybenzyloxy)-3-methyl-1-triethylsilanyloxy-hex-5-ynyl]-tetrahydro-furan-2-yl}-but-1-enyl)-2,2-dimethyl-5-vinyl-[1,3]dioxolane

Guidance literature:: With 4 A molecular sieve; boron trifluoride diethyl etherate; In dichloromethane; at -78 ℃; for 21h;
DOI:10.1021/ja066663j

Reference yield:

: 1-((4R,5R)-2,2-Dimethyl-5-vinyl-[1,3]dioxolan-4-yl)-prop-2-en-1-ol

: 921763-52-2
(4R,5R)-4-((E)-4-{(2S,4S,5R)-4-(dimethyl-phenyl-silanyl)-5-[(1S,2R,3R)-2-(4-methoxybenzyloxy)-3-methyl-1-triethylsilanyloxy-hex-5-ynyl]-tetrahydro-furan-2-yl}-but-1-enyl)-2,2-dimethyl-5-vinyl-[1,3]dioxolane

Guidance literature:: Multi-step reaction with 3 steps

1: 2.83 g / propionic acid / toluene / 18 h / Heating

2: 81 percent / DIBAL / toluene; hexane / 0.5 h / -78 °C

3: 48 percent / 4 Angstroem molecular sieves; BF₃*OEt₂ / CH₂Cl₂ / 21 h / -78 °C

With 4 A molecular sieve; boron trifluoride diethyl etherate; diisobutylaluminium hydride; propionic acid; In hexane; dichloromethane; toluene; 1: Claisen rearrangement;
DOI:10.1021/ja066663j

Reference yield:

: 921763-55-5
(E)-5-((4R,5R)-2,2-dimethyl-5-vinyl-[1,3]dioxolan-4-yl)-pent-4-enoic acid methyl ester

: 921763-52-2
(4R,5R)-4-((E)-4-{(2S,4S,5R)-4-(dimethyl-phenyl-silanyl)-5-[(1S,2R,3R)-2-(4-methoxybenzyloxy)-3-methyl-1-triethylsilanyloxy-hex-5-ynyl]-tetrahydro-furan-2-yl}-but-1-enyl)-2,2-dimethyl-5-vinyl-[1,3]dioxolane

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / DIBAL / toluene; hexane / 0.5 h / -78 °C

2: 48 percent / 4 Angstroem molecular sieves; BF₃*OEt₂ / CH₂Cl₂ / 21 h / -78 °C

With 4 A molecular sieve; boron trifluoride diethyl etherate; diisobutylaluminium hydride; In hexane; dichloromethane; toluene;
DOI:10.1021/ja066663j