Cyclopentanecarboxaldehyde, 4-hydroxy-2,3-bis(phenylmethoxy)-, (1S,2R,3S,4S)-

Base Information

Chemical Name:Cyclopentanecarboxaldehyde, 4-hydroxy-2,3-bis(phenylmethoxy)-, (1S,2R,3S,4S)-
CAS No.:921771-03-1
Molecular Formula:C20H22O4
Molecular Weight:326.392
Hs Code.:

Synonyms:

Suppliers and Price of Cyclopentanecarboxaldehyde, 4-hydroxy-2,3-bis(phenylmethoxy)-, (1S,2R,3S,4S)-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Cyclopentanecarboxaldehyde, 4-hydroxy-2,3-bis(phenylmethoxy)-, (1S,2R,3S,4S)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Cyclopentanecarboxaldehyde, 4-hydroxy-2,3-bis(phenylmethoxy)-, (1S,2R,3S,4S)-

There total 11 articles about Cyclopentanecarboxaldehyde, 4-hydroxy-2,3-bis(phenylmethoxy)-, (1S,2R,3S,4S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 921771-02-0
(S)-1-((1R,2R,3S,4S)-2,3-Bis-benzyloxy-4-hydroxy-cyclopentyl)-ethane-1,2-diol

: 921771-03-1
(1S,2R,3S,4S)-2,3-Bis-benzyloxy-4-hydroxy-cyclopentanecarbaldehyde

Guidance literature:: With sodium periodate; In methanol; water; at 0 ℃; for 0.5h;
DOI:10.1021/jo061717t

Reference yield:

: 763105-46-0
(S)-(S)-4-(1,4-Dioxa-spiro[4.5]dec-2-yl)-cyclopent-2-enol

: 921771-03-1
(1S,2R,3S,4S)-2,3-Bis-benzyloxy-4-hydroxy-cyclopentanecarbaldehyde

Guidance literature:: Multi-step reaction with 10 steps

1.1: 96 percent / Jones reagent / acetone / 0.5 h / 0 °C

2.1: 79 percent / LiAlH₄ / diethyl ether / 1 h / -60 °C

3.1: 96 percent / triethylamine; DMAP; imidazole / CH₂Cl₂ / 18 h / 20 °C

4.1: 96 percent / N-methyl-morpholine N-oxide monohydrate / OsO₄ / acetone; H₂O / 14 h / 20 °C

5.1: NaH / tetrahydrofuran / 2 h / 20 °C

5.2: 91 percent / HMPA / tetrahydrofuran / 12 h / 20 °C

6.1: 90 percent / n-Bu₄N(+)F(-)*3H₂O / tetrahydrofuran / 2 h / 20 °C

7.1: 87 percent / Jones reagent / acetone / 0.5 h / 0 °C

8.1: 60 percent / LiAlH₄ / diethyl ether / 1 h / -60 °C

9.1: 60 percent / aq. acetic acid / 17 h / 20 °C

10.1: 87 percent / NaIO₄ / methanol; H₂O / 0.5 h / 0 °C

With 1H-imidazole; dmap; sodium periodate; lithium aluminium tetrahydride; jones reagent; tetrabutyl ammonium fluoride; sodium hydride; acetic acid; 4-methylmorpholine N-oxide; triethylamine; osmium(VIII) oxide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; acetone;
DOI:10.1021/jo061717t

Reference yield:

: 921770-86-7
(4S)-4-[(2S)-1,4-dioxaspiro[4.5]dec-2-yl]cyclopent-2-en-1-one

: 921771-03-1
(1S,2R,3S,4S)-2,3-Bis-benzyloxy-4-hydroxy-cyclopentanecarbaldehyde

Guidance literature:: Multi-step reaction with 9 steps

1.1: 79 percent / LiAlH₄ / diethyl ether / 1 h / -60 °C

2.1: 96 percent / triethylamine; DMAP; imidazole / CH₂Cl₂ / 18 h / 20 °C

3.1: 96 percent / N-methyl-morpholine N-oxide monohydrate / OsO₄ / acetone; H₂O / 14 h / 20 °C

4.1: NaH / tetrahydrofuran / 2 h / 20 °C

4.2: 91 percent / HMPA / tetrahydrofuran / 12 h / 20 °C

5.1: 90 percent / n-Bu₄N(+)F(-)*3H₂O / tetrahydrofuran / 2 h / 20 °C

6.1: 87 percent / Jones reagent / acetone / 0.5 h / 0 °C

7.1: 60 percent / LiAlH₄ / diethyl ether / 1 h / -60 °C

8.1: 60 percent / aq. acetic acid / 17 h / 20 °C

9.1: 87 percent / NaIO₄ / methanol; H₂O / 0.5 h / 0 °C

With 1H-imidazole; dmap; sodium periodate; lithium aluminium tetrahydride; jones reagent; tetrabutyl ammonium fluoride; sodium hydride; acetic acid; 4-methylmorpholine N-oxide; triethylamine; osmium(VIII) oxide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; acetone;
DOI:10.1021/jo061717t