(1-Benzylpyrrolidine-2,5-diyl)diMethanol

Base Information

• Chemical Name: (1-Benzylpyrrolidine-2,5-diyl)diMethanol
• CAS No.: 92197-46-1
• Molecular Formula: C13H19NO2
• Molecular Weight: 221.299
• Mol file: 92197-46-1.mol

Synonyms:1-BENZYL-2,5-PYRROLIDINEDIMETHANOL;(1-Benzylpyrrolidine-2,5-diyl)dimethanol;1-BENZYL-2,5-BIS(HYDROXYMETHYL)PYRROLIDINE;

Chemical Property of (1-Benzylpyrrolidine-2,5-diyl)diMethanol

Chemical Property:

• PSA: 43.70000
• LogP: 0.94210

Purity/Quality:

97% ^*data from raw suppliers

(1-Benzylpyrrolidine-2,5-diyl)dimethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (1-Benzylpyrrolidine-2,5-diyl)diMethanol

There total 4 articles about (1-Benzylpyrrolidine-2,5-diyl)diMethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-methyl ester + 1-benzyl-pyrrolidine-2,5-dicarboxylic acid → (1-benzyl-5-hydroxymethyl-pyrrolidine-2-yl)-methanol (92197-46-1)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; water;

Reference yield:

diethyl meso-1-benzyl-2,5-pyrrolidinedicarboxylate (17740-40-8) → (1-benzyl-5-hydroxymethyl-pyrrolidine-2-yl)-methanol (92197-46-1)

Guidance literature:

In tetrahydrofuran; water;

Reference yield:

1-benzyl-pyrrolidine-2,5-dicarboxylic acid, 2-ethyl ester, 5-methyl ester → (1-benzyl-5-hydroxymethyl-pyrrolidine-2-yl)-methanol (92197-46-1)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 3h;

upstream raw materials:

diethyl meso-1-benzyl-2,5-pyrrolidinedicarboxylate

Downstream raw materials:

1-benzyl-2,5-bis(chloromethyl)-pyrrolidine

1-benzyl-2-t-butyldimethylsilyloxymethyl-5-hydroxymethylpyrrolidine

2-benzyl-5-(4-fluoro-phenyl)-2,5-diaza-bicyclo[2.2.2]octane

8-benzyl-3-(4-fluoro-phenyl)-3,8-diaza-bicyclo[3.2.1]octane