4H-Pyran-2-carboxamide, N-[(4-fluorophenyl)methyl]-6-methyl-4-oxo-3-(phenylmethoxy)-

Base Information

Chemical Name:4H-Pyran-2-carboxamide, N-[(4-fluorophenyl)methyl]-6-methyl-4-oxo-3-(phenylmethoxy)-
CAS No.:922159-35-1
Molecular Formula:C21H18FNO4
Molecular Weight:367.377
Hs Code.:

Synonyms:

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Chemical Property of 4H-Pyran-2-carboxamide, N-[(4-fluorophenyl)methyl]-6-methyl-4-oxo-3-(phenylmethoxy)-

Chemical Property:

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Technology Process of 4H-Pyran-2-carboxamide, N-[(4-fluorophenyl)methyl]-6-methyl-4-oxo-3-(phenylmethoxy)-

There total 9 articles about 4H-Pyran-2-carboxamide, N-[(4-fluorophenyl)methyl]-6-methyl-4-oxo-3-(phenylmethoxy)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 140-75-0
para-fluorobenzylamine

: 216581-47-4
3-(benzyloxy)-6-methyl-4-oxo-4H-pyran-2-carboxylic acid

: 922159-35-1
C₂₁H₁₈FNO₄

Guidance literature:: With diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

Reference yield:

: 644-46-2
allomaltol

: 922159-35-1
C₂₁H₁₈FNO₄

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydroxide / 1,4-dioxane; water / 4.08 h

2: sodium hydroxide / methanol; water / 12 h / Heating / reflux

3: sulfur trioxide pyridine complex; triethylamine / dichloromethane; dimethyl sulfoxide / 12 h / 5 - 20 °C

4: sodium chlorite; aminosulfonic acid / water; acetone / 2 h / 20 °C

5: diisopropylamine; HATU / N,N-dimethyl-formamide / 24 h / 20 °C

With sodium hydroxide; sodium chlorite; aminosulfonic acid; sulfur trioxide pyridine complex; triethylamine; diisopropylamine; HATU; In 1,4-dioxane; methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone;

Reference yield:

: 501-30-4,123712-78-7
5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

: 922159-35-1
C₂₁H₁₈FNO₄

Guidance literature:: Multi-step reaction with 7 steps

1: thionyl chloride / dichloromethane / 2 h / 20 °C

2: hydrogenchloride; zinc / water / 15 h / 70 °C

3: sodium hydroxide / 1,4-dioxane; water / 4.08 h

4: sodium hydroxide / methanol; water / 12 h / Heating / reflux

5: sulfur trioxide pyridine complex; triethylamine / dichloromethane; dimethyl sulfoxide / 12 h / 5 - 20 °C

6: sodium chlorite; aminosulfonic acid / water; acetone / 2 h / 20 °C

7: diisopropylamine; HATU / N,N-dimethyl-formamide / 24 h / 20 °C

With hydrogenchloride; sodium hydroxide; sodium chlorite; thionyl chloride; aminosulfonic acid; sulfur trioxide pyridine complex; triethylamine; diisopropylamine; HATU; zinc; In 1,4-dioxane; methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone;