4H-Pyran-2-carboxamide, N-[(4-fluorophenyl)methyl]-3-hydroxy-6-methyl-4-oxo-

Base Information

• Chemical Name: 4H-Pyran-2-carboxamide, N-[(4-fluorophenyl)methyl]-3-hydroxy-6-methyl-4-oxo-
• CAS No.: 922159-37-3
• Molecular Formula: C14H12FNO4
• Molecular Weight: 277.252
• Mol file: 922159-37-3.mol

Synonyms:

Chemical Property of 4H-Pyran-2-carboxamide, N-[(4-fluorophenyl)methyl]-3-hydroxy-6-methyl-4-oxo-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4H-Pyran-2-carboxamide, N-[(4-fluorophenyl)methyl]-3-hydroxy-6-methyl-4-oxo-

There total 8 articles about 4H-Pyran-2-carboxamide, N-[(4-fluorophenyl)methyl]-3-hydroxy-6-methyl-4-oxo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

C21H18FNO4 (922159-35-1) → C14H12FNO4 (922159-37-3)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In ethanol; at 20 ℃; for 1h;

Reference yield:

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one (501-30-4,123712-78-7) → C14H12FNO4 (922159-37-3)

Guidance literature:

Multi-step reaction with 8 steps

1: thionyl chloride / dichloromethane / 2 h / 20 °C

2: hydrogenchloride; zinc / water / 15 h / 70 °C

3: sodium hydroxide / 1,4-dioxane; water / 4.08 h

4: sodium hydroxide / methanol; water / 12 h / Heating / reflux

5: sulfur trioxide pyridine complex; triethylamine / dichloromethane; dimethyl sulfoxide / 12 h / 5 - 20 °C

6: sodium chlorite; aminosulfonic acid / water; acetone / 2 h / 20 °C

7: diisopropylamine; HATU / N,N-dimethyl-formamide / 24 h / 20 °C

8: hydrogen / palladium 10% on activated carbon / ethanol / 1 h / 20 °C

With hydrogenchloride; sodium hydroxide; sodium chlorite; thionyl chloride; aminosulfonic acid; hydrogen; sulfur trioxide pyridine complex; triethylamine; diisopropylamine; HATU; zinc; palladium 10% on activated carbon; In 1,4-dioxane; methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone;

Reference yield:

chlorokojic acid (7559-81-1,54839-86-0) → C14H12FNO4 (922159-37-3)

Guidance literature:

Multi-step reaction with 7 steps

1: hydrogenchloride; zinc / water / 15 h / 70 °C

2: sodium hydroxide / 1,4-dioxane; water / 4.08 h

3: sodium hydroxide / methanol; water / 12 h / Heating / reflux

4: sulfur trioxide pyridine complex; triethylamine / dichloromethane; dimethyl sulfoxide / 12 h / 5 - 20 °C

5: sodium chlorite; aminosulfonic acid / water; acetone / 2 h / 20 °C

6: diisopropylamine; HATU / N,N-dimethyl-formamide / 24 h / 20 °C

7: hydrogen / palladium 10% on activated carbon / ethanol / 1 h / 20 °C

With hydrogenchloride; sodium hydroxide; sodium chlorite; aminosulfonic acid; hydrogen; sulfur trioxide pyridine complex; triethylamine; diisopropylamine; HATU; zinc; palladium 10% on activated carbon; In 1,4-dioxane; methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone;

upstream raw materials:

C₂₁H₁₈FNO₄

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

chlorokojic acid

2-hydroxymethyl-3-hydroxy-6-methyl-pyran-4(1H)-one