Acetamide, N-(2-(4-(hexahydro-1H-azepin-1-yl)-3-nitrophenyl)-4-oxo-3(4H)-quinazolinyl)-2-((4-(2-phenyl-1,8-naphthyridin-3-yl)carbonyl)phenoxy)-

Base Information

Chemical Name:Acetamide, N-(2-(4-(hexahydro-1H-azepin-1-yl)-3-nitrophenyl)-4-oxo-3(4H)-quinazolinyl)-2-((4-(2-phenyl-1,8-naphthyridin-3-yl)carbonyl)phenoxy)-
CAS No.:136603-31-1
Molecular Formula:C₄₃H₃₅N₇O₆
Molecular Weight:745.794
Hs Code.:
DSSTox Substance ID:DTXSID90159854
Wikidata:Q83028232

Acetamide, N-(2-(4-(hexahydro-1H-azepin-1-yl)-3-nitrophenyl)-4-oxo-3(4H)-quinazolinyl)-2-((4-(2-phenyl-1,8-naphthyridin-3-yl)carbonyl)phenoxy)-

Synonyms:BRN 4900506;Acetamide, N-(2-(4-(hexahydro-1H-azepin-1-yl)-3-nitrophenyl)-4-oxo-3(4H)-quinazolinyl)-2-((4-(2-phenyl-1,8-naphthyridin-3-yl)carbonyl)phenoxy)-;136603-31-1;DTXSID90159854;C43H35N7O6;C43-H35-N7-O6;LS-9651

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Chemical Property of Acetamide, N-(2-(4-(hexahydro-1H-azepin-1-yl)-3-nitrophenyl)-4-oxo-3(4H)-quinazolinyl)-2-((4-(2-phenyl-1,8-naphthyridin-3-yl)carbonyl)phenoxy)-

Chemical Property:

Boiling Point:°Cat760mmHg
Flash Point:°C
Density:1.38g/cm³
XLogP3:7.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:8
Exact Mass:745.26488186
Heavy Atom Count:56
Complexity:1420

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CCCN(CC1)C2=C(C=C(C=C2)C3=NC4=CC=CC=C4C(=O)N3NC(=O)COC5=CC=C(C=C5)C(=O)C6=C(N=C7C(=C6)C=CC=N7)C8=CC=CC=C8)[N+](=O)[O-]

Technology Process of Acetamide, N-(2-(4-(hexahydro-1H-azepin-1-yl)-3-nitrophenyl)-4-oxo-3(4H)-quinazolinyl)-2-((4-(2-phenyl-1,8-naphthyridin-3-yl)carbonyl)phenoxy)-

There total 5 articles about Acetamide, N-(2-(4-(hexahydro-1H-azepin-1-yl)-3-nitrophenyl)-4-oxo-3(4H)-quinazolinyl)-2-((4-(2-phenyl-1,8-naphthyridin-3-yl)carbonyl)phenoxy)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7521-41-7
2-Aminonicotinaldehyde

: 136603-31-1
N-[2-(4-Azepan-1-yl-3-nitro-phenyl)-4-oxo-4H-quinazolin-3-yl]-2-[4-(2-phenyl-[1,8]naphthyridine-3-carbonyl)-phenoxy]-acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: conc. H₂SO₄, glac. AcOH

2: 65 percent / K₂CO₃ / acetone / 18 h / Heating

3: 60 percent / hydrazine hydrate / methanol / 8 h / Heating

4: 60 percent / 1) heating, 2 min, 2) CH₃OH, r.t., overnight

5: pyridine / 24 h / Heating

With sulfuric acid; potassium carbonate; hydrazine hydrate; acetic acid; In pyridine; methanol; acetone;

Reference yield:

: 52046-71-6
1-(4-hydroxy-phenyl)-3-phenyl-propane-1,3-dione

: 136603-31-1
N-[2-(4-Azepan-1-yl-3-nitro-phenyl)-4-oxo-4H-quinazolin-3-yl]-2-[4-(2-phenyl-[1,8]naphthyridine-3-carbonyl)-phenoxy]-acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: conc. H₂SO₄, glac. AcOH

2: 65 percent / K₂CO₃ / acetone / 18 h / Heating

3: 60 percent / hydrazine hydrate / methanol / 8 h / Heating

4: 60 percent / 1) heating, 2 min, 2) CH₃OH, r.t., overnight

5: pyridine / 24 h / Heating

With sulfuric acid; potassium carbonate; hydrazine hydrate; acetic acid; In pyridine; methanol; acetone;

Reference yield:

: 116625-85-5
3-p-Hydroxybenzoyl-2-phenyl-1,8-naphthyridine

: 136603-31-1
N-[2-(4-Azepan-1-yl-3-nitro-phenyl)-4-oxo-4H-quinazolin-3-yl]-2-[4-(2-phenyl-[1,8]naphthyridine-3-carbonyl)-phenoxy]-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: 65 percent / K₂CO₃ / acetone / 18 h / Heating

2: 60 percent / hydrazine hydrate / methanol / 8 h / Heating

3: 60 percent / 1) heating, 2 min, 2) CH₃OH, r.t., overnight

4: pyridine / 24 h / Heating

With potassium carbonate; hydrazine hydrate; In pyridine; methanol; acetone;