Ripazepam

Base Information

• Chemical Name: Ripazepam
• CAS No.: 26308-28-1
• Molecular Formula: C15H16 N4 O
• Molecular Weight: 268.318
• Hs Code.: 2933990090
• UNII: 92000WH9C9
• DSSTox Substance ID: DTXSID1021245
• Nikkaji Number: J20.440D
• Wikipedia: Ripazepam
• Wikidata: Q7335571
• NCI Thesaurus Code: C98140
• ChEMBL ID: CHEMBL159298
• Mol file: 26308-28-1.mol

Synonyms:CI 683;CI-683;pyrazapon;ripazepam

Chemical Property of Ripazepam

Chemical Property:

• Vapor Pressure: 6.97E-09mmHg at 25°C
• Melting Point: 214°C
• Refractive Index: 1.6500 (estimate)
• Boiling Point: 466.6°C at 760 mmHg
• PKA: 12.96±0.40(Predicted)
• Flash Point: 236°C
• PSA: 59.28000
• Density: 1.28g/cm³
• LogP: 1.57450
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 268.13241115
• Heavy Atom Count: 20
• Complexity: 403

Purity/Quality:

99% ^*data from raw suppliers

1-ETHYL-3-METHYL-8-PHENYL-4,6-DIHYDROPYRAZOLO[4,3-E][1,4]DIAZEPIN-5(1H)-ONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCN1C2=C(C(=N1)C)NC(=O)CN=C2C3=CC=CC=C3
• Uses: Tranquilizer (minor).

Technology Process of Ripazepam

There total 1 articles about Ripazepam which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ Ripazepam (26308-28-1)

Guidance literature:

77,NH3;

DOI:10.1021/jm00270a007

Reference yield: 65.0%

Ripazepam (26308-28-1) → 1-Ethyl-3-methyl-8-phenyl-4,6-dihydro-1H-pyrazolo[4,3-e][1,4]diazepine-5-thione (104472-96-0)

Guidance literature:

With n-butyllithium; tetraphosphorus decasulfide; In tetrahydrofuran; hexane; for 16h; Heating;

DOI:10.1055/s-1987-27871

Downstream raw materials:

1-Ethyl-3-methyl-8-phenyl-4,6-dihydro-1H-pyrazolo[4,3-e][1,4]diazepine-5-thione

Refernces