Quinoxaline, 5,6,7,8-tetrahydro-, 1-oxide

Base Information

• Chemical Name: Quinoxaline, 5,6,7,8-tetrahydro-, 1-oxide
• CAS No.: 922525-11-9
• Molecular Formula: C8H10N2O
• Molecular Weight: 150.18
• Mol file: 922525-11-9.mol

Synonyms:5,6,7,8-tetrahydro-quinoxaline 1-oxide;5,6,7,8-tetrahydroquinoxaline N-oxide;5,6,7,8-tetrahydroquinoxaline-1-oxide;

Chemical Property of Quinoxaline, 5,6,7,8-tetrahydro-, 1-oxide

Chemical Property:

• Melting Point: 74.1-75.0 °C
• Boiling Point: 382.1±37.0 °C(Predicted)
• PSA: 38.35000
• Density: 1.28±0.1 g/cm3(Predicted)
• LogP: 1.38890

Purity/Quality:

5,6,7,8-tetrahydro-Quinoxaline1-oxide 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Quinoxaline, 5,6,7,8-tetrahydro-, 1-oxide

There total 2 articles about Quinoxaline, 5,6,7,8-tetrahydro-, 1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

5,6,7,8-tetrahydroquinoxaline (34413-35-9) → 5,6,7,8-tetrahydroquinoxaline N-oxide (922525-11-9)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃;

DOI:10.1021/acs.jmedchem.8b01609

Reference yield: 77.0%

→ 5,6,7,8-tetrahydroquinoxaline N-oxide (922525-11-9)

Guidance literature:

Reference yield: 56.0%

5,6,7,8-tetrahydroquinoxaline N-oxide (922525-11-9) + para-bromotoluene (106-38-7) → 5,6,7,8-tetrahydro-2-p-tolylquinoxaline 1-oxide

Guidance literature:

With potassium carbonate; tri tert-butylphosphoniumtetrafluoroborate; palladium diacetate; In 1,4-dioxane; at 110 ℃;

DOI:10.1002/anie.200602773

upstream raw materials:

5,6,7,8-tetrahydroquinoxaline