Technology Process of Pentanoic acid,
5-diazo-3-[methyl[(phenylmethoxy)carbonyl]amino]-4-oxo-, phenylmethyl
ester, (3S)-
There total 4 articles about Pentanoic acid,
5-diazo-3-[methyl[(phenylmethoxy)carbonyl]amino]-4-oxo-, phenylmethyl
ester, (3S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(2S)-2-(methyl{[(phenylmethyl)oxy]carbonyl}amino)-4-oxo-4-[(phenylmethyl)oxy]butanoic acid;
With
4-methyl-morpholine; chloroformic acid ethyl ester;
In
tetrahydrofuran;
at -15 ℃;
for 0.25h;
diazomethane;
In
tetrahydrofuran; dichloromethane;
at -15 - 20 ℃;
DOI:10.1002/hlca.200690235
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: CSA / toluene / Heating
2.1: Et3N; 4-(dimethylamino)pyridine / CH2Cl2 / 0 °C
3.1: Et3SiH; TFA / CH2Cl2
4.1: ClCOOEt; N-methylmorpholine / tetrahydrofuran / 0.25 h / -15 °C
4.2: 50 percent / tetrahydrofuran; CH2Cl2 / -15 - 20 °C
With
4-methyl-morpholine; triethylsilane; dmap; chloroformic acid ethyl ester; triethylamine; trifluoroacetic acid;
camphor-10-sulfonic acid;
In
tetrahydrofuran; dichloromethane; toluene;
DOI:10.1002/hlca.200690235
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: Et3N; 4-(dimethylamino)pyridine / CH2Cl2 / 0 °C
2.1: Et3SiH; TFA / CH2Cl2
3.1: ClCOOEt; N-methylmorpholine / tetrahydrofuran / 0.25 h / -15 °C
3.2: 50 percent / tetrahydrofuran; CH2Cl2 / -15 - 20 °C
With
4-methyl-morpholine; triethylsilane; dmap; chloroformic acid ethyl ester; triethylamine; trifluoroacetic acid;
In
tetrahydrofuran; dichloromethane;
DOI:10.1002/hlca.200690235
