3-(4-methylphenyl)-2-{[1-(2-oxopyrrolidin-1-yl)-3-(piperidin-1-yl)propan-2-yl]sulfanyl}quinazolin-4(3H)-one hydrochloride (1:1)

Base Information

Chemical Name:3-(4-methylphenyl)-2-{[1-(2-oxopyrrolidin-1-yl)-3-(piperidin-1-yl)propan-2-yl]sulfanyl}quinazolin-4(3H)-one hydrochloride (1:1)
CAS No.:117039-00-6
Molecular Formula:C₂₇H₃₂N₄O₂S*ClH
Molecular Weight:513.104
Hs Code.:
Mol file:117039-00-6.mol

Synonyms:4(3H)-Quinazolinone,3-(4-methylphenyl)-2-[[1-[(2-oxo-1-pyrrolidinyl)methyl]-2-(1-piperidinyl)ethyl]thio]-,monohydrochloride (9CI)

Suppliers and Price of 3-(4-methylphenyl)-2-{[1-(2-oxopyrrolidin-1-yl)-3-(piperidin-1-yl)propan-2-yl]sulfanyl}quinazolin-4(3H)-one hydrochloride (1:1)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 3-(4-methylphenyl)-2-{[1-(2-oxopyrrolidin-1-yl)-3-(piperidin-1-yl)propan-2-yl]sulfanyl}quinazolin-4(3H)-one hydrochloride (1:1)

Chemical Property:

Vapor Pressure:7.05E-19mmHg at 25°C
Boiling Point:689.8°Cat760mmHg
Flash Point:371°C
Density:g/cm³

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 3-(4-methylphenyl)-2-{[1-(2-oxopyrrolidin-1-yl)-3-(piperidin-1-yl)propan-2-yl]sulfanyl}quinazolin-4(3H)-one hydrochloride (1:1)

There total 2 articles about 3-(4-methylphenyl)-2-{[1-(2-oxopyrrolidin-1-yl)-3-(piperidin-1-yl)propan-2-yl]sulfanyl}quinazolin-4(3H)-one hydrochloride (1:1) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 117039-16-4
1-(2-Chloro-3-piperidin-1-yl-propyl)-pyrrolidin-2-one; hydrochloride

: 37641-50-2
2-Mercapto-3-(4-methylphenyl)-3,4-dihydroquinazolin-4-one

: 117039-00-6
2-[2-(2-Oxo-pyrrolidin-1-yl)-1-piperidin-1-ylmethyl-ethylsulfanyl]-3-p-tolyl-3H-quinazolin-4-one; hydrochloride

Guidance literature:: With sodium carbonate; In water; acetone; for 12h; Heating;
DOI:10.1007/BF00763531

Reference yield:

: 117039-12-0
1-(2-Hydroxy-3-piperidin-1-yl-propyl)-pyrrolidin-2-one

: 117039-00-6
2-[2-(2-Oxo-pyrrolidin-1-yl)-1-piperidin-1-ylmethyl-ethylsulfanyl]-3-p-tolyl-3H-quinazolin-4-one; hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / SOCl₂ / CHCl₃ / 24 h / 20 °C

2: 55 percent / Na₂CO₃ / acetone; H₂O / 12 h / Heating

With thionyl chloride; sodium carbonate; In chloroform; water; acetone;
DOI:10.1007/BF00763531