Technology Process of 2H-Pyran,
tetrahydro-2-[(2,6,6-trimethyl-1,3-cyclohexadien-1-yl)methoxy]-
There total 1 articles about 2H-Pyran,
tetrahydro-2-[(2,6,6-trimethyl-1,3-cyclohexadien-1-yl)methoxy]- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
toluene-4-sulfonic acid;
In
dichloromethane;
at 0 ℃;
for 0.166667h;
DOI:10.1139/V06-092
- Guidance literature:
-
tetrahydropyran-2-yl safranol; 9-bora-bicyclo[3.3.1]nonane;
In
tetrahydrofuran;
at 60 ℃;
for 4h;
With
sodium hydroxide; dihydrogen peroxide;
In
methanol; dichloromethane; water;
at 55 ℃;
for 2h;
DOI:10.1139/V06-092
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: tetrahydrofuran / 4 h / 60 °C
1.2: 55 percent / NaOH; H2O2 / CH2Cl2; methanol; H2O / 2 h / 55 °C
2.1: pyridine / 12 h / 20 °C
3.1: 576 mg / p-toluenesulfonic acid / methanol / 12 h / 20 °C
4.1: 94 percent / triphenylphosphine; carbon tetrabromide / 1 h / 20 °C
5.1: 1.37 g / benzene / 12 h / Heating
6.1: n-BuLi / tetrahydrofuran; hexane / -78 - 20 °C
6.2: 40 percent / tetrahydrofuran; hexane / 14 h / 20 °C
7.1: 63 percent / 4-(dimethylamino)pyridine; pyridine / 12 h / 20 °C
8.1: 99 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0 - 20 °C
9.1: 84 percent / MnO2 / CH2Cl2 / 0 - 20 °C
10.1: NaH / tetrahydrofuran / 0 - 20 °C
10.2: 27 percent / tetrahydrofuran / 12 h / 20 °C
With
pyridine; dmap; manganese(IV) oxide; n-butyllithium; carbon tetrabromide; tetrabutyl ammonium fluoride; sodium hydride; toluene-4-sulfonic acid; triphenylphosphine;
In
tetrahydrofuran; methanol; hexane; dichloromethane; benzene;
6.2: Wittig reaction / 10.2: Horner-Emmons-Wadsworth reaction;
DOI:10.1139/V06-092
