Technology Process of 1-Pyrrolidinecarboxylic acid, 3-azido-4-hydroxy-, phenylmethyl ester,
(3R,4S)-
There total 11 articles about 1-Pyrrolidinecarboxylic acid, 3-azido-4-hydroxy-, phenylmethyl ester,
(3R,4S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
Pseudomonas cepacia lipase immobilized on diatomaceous earth;
In
di-isopropyl ether;
at 40 ℃;
for 14h;
DOI:10.1016/j.tetasy.2006.10.031
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 90 percent / Grubbs catalyst / CH2Cl2 / 6 h / 20 °C
2: 86 percent / H2O; N-bromosuccinimide / dimethylsulfoxide / 2 h / 20 °C
3: 82 percent / sodium hydroxide / methanol; H2O / 1 h / 20 °C
4: 86 percent / sodium azide / dioxane; H2O / 12 h / 100 °C
5: 90 percent / Et3N / CH2Cl2 / 4 h / 20 °C
6: 86 percent / dimethylformamide / 3 h / 100 °C
7: 98 percent / anhydrous K2CO3 / methanol / 1 h / 20 °C
8: Pseudomonas cepacia lipase immobilized on diatomaceous earth / diisopropyl ether / 14 h / 40 °C
With
sodium hydroxide; N-Bromosuccinimide; sodium azide; Pseudomonas cepacia lipase immobilized on diatomaceous earth; water; potassium carbonate; triethylamine;
Grubbs catalyst first generation;
In
1,4-dioxane; methanol; dichloromethane; di-isopropyl ether; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.tetasy.2006.10.031
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 92 percent / Et3N / CH2Cl2; toluene / 10 h / 20 °C
2: 90 percent / Grubbs catalyst / CH2Cl2 / 6 h / 20 °C
3: 86 percent / H2O; N-bromosuccinimide / dimethylsulfoxide / 2 h / 20 °C
4: 82 percent / sodium hydroxide / methanol; H2O / 1 h / 20 °C
5: 86 percent / sodium azide / dioxane; H2O / 12 h / 100 °C
6: 90 percent / Et3N / CH2Cl2 / 4 h / 20 °C
7: 86 percent / dimethylformamide / 3 h / 100 °C
8: 98 percent / anhydrous K2CO3 / methanol / 1 h / 20 °C
9: Pseudomonas cepacia lipase immobilized on diatomaceous earth / diisopropyl ether / 14 h / 40 °C
With
sodium hydroxide; N-Bromosuccinimide; sodium azide; Pseudomonas cepacia lipase immobilized on diatomaceous earth; water; potassium carbonate; triethylamine;
Grubbs catalyst first generation;
In
1,4-dioxane; methanol; dichloromethane; di-isopropyl ether; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.tetasy.2006.10.031
