Rabeprazole

Base Information Edit

Chemical Name:Rabeprazole
CAS No.:117976-89-3
Deprecated CAS:909251-57-6
Molecular Formula:C18H21N3O3S
Molecular Weight:359.449
Hs Code.:
European Community (EC) Number:601-501-2
UNII:32828355LL
DSSTox Substance ID:DTXSID3044122
Nikkaji Number:J395.966J
Wikipedia:Rabeprazole
Wikidata:Q3515
NCI Thesaurus Code:C29410
RXCUI:114979
Pharos Ligand ID:6VLRUMLPVKYA
Metabolomics Workbench ID:38710
ChEMBL ID:CHEMBL1219
Mol file:117976-89-3.mol

Synonyms:1H-Benzimidazole, 2-(((4-(3-methoxypropoxy)-3-methyl-2-pyridinyl)methyl)sulfinyl)-, sodium salt;2-((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methylsulfinyl)-1H-benzimidazole;Aciphex;dexrabeprazole;E 3810;E3810;LY 307640;LY-307640;LY307640;Pariet;rabeprazole;rabeprazole sodium;Sodium, Rabeprazole

Suppliers and Price of Rabeprazole

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Rabeprazole
500mg
$ 875.00

Medical Isotopes, Inc.
Rabeprazole
50 mg
$ 610.00

Matrix Scientific
Rabeprazole
1g
$ 227.00

CSNpharm
Rabeprazole
1mg
$ 35.00

CSNpharm
Rabeprazole
10mg
$ 109.00

Crysdot
Rabeprazole 98+%
50mg
$ 287.00

Chemenu
1h-benzimidazole,2-[[[4-(3-methoxypropoxy)-3-methyl-2-pyridinyl]methyl]sulfinyl]- 97%
10g
$ 660.00

Chemenu
1h-benzimidazole,2-[[[4-(3-methoxypropoxy)-3-methyl-2-pyridinyl]methyl]sulfinyl]- 97%
5g
$ 396.00

Biosynth Carbosynth
Rabeprazole
2 g
$ 180.00

Biosynth Carbosynth
Rabeprazole
10 g
$ 550.00

Total 130 raw suppliers

Chemical Property of Rabeprazole Edit

Chemical Property:

Appearance/Colour:white to yellowish crystalline powder
Vapor Pressure:0mmHg at 25°C
Melting Point:202-204°C
Refractive Index:1.505
Boiling Point:603.9 °C at 760 mmHg
PKA:9.57±0.10(Predicted)
Flash Point:319.1 °C
PSA：96.31000
Density:1.33 g/cm³
LogP:3.85510
Storage Temp.:Inert atmosphere,Store in freezer, under -20°C
Solubility.:DMSO (Slightly), Methanol (Slightly)
XLogP3:1.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:8
Exact Mass:359.13036271
Heavy Atom Count:25
Complexity:440

Purity/Quality:

98%min ^*data from raw suppliers

Rabeprazole ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 36/38
Safety Statements: 26-37/39

MSDS Files:: SDS file from LookChem

Useful:

Drug Classes:Antiulcer Agents
Canonical SMILES:CC1=C(C=CN=C1CS(=O)C2=NC3=CC=CC=C3N2)OCCCOC
Recent ClinicalTrials:Efficacy of Therapy Based on Fecal Molecular Antimicrobial Susceptibility Tests for Helicobacter Pylori Infection
Recent EU Clinical Trials:ASSOCIATION BETWEEN PROTON-PUMP INHIBITORS (PPI) and METRONOMIC CAPECITABINE (mCAP) AS SALVAGE TREATMENT FOR PATIENTS WITH ADVANCED GASTRO-INTESTINAL TUMOURS: A RANDOMIZED PHASE II STUDY
Recent NIPH Clinical Trials:Berberine containing therapy for Helicobacter Pylori treatment among patients with previous failed eradication
Uses Rabeprazole is used to treat hyperacidity. It is a proton pump inhibitor that helps heal gastrointestinal ulcers, treats gastroesophageal reflux disease, and also treats hypersecretory disorders.

Technology Process of Rabeprazole

There total 17 articles about Rabeprazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1080503-70-3
2,3-dimethyl-4-(3-methoxy-propoxy)pyridine

: 1080503-68-9
(-)-menthyl 2-benzimidazolylsulphinate

: 117976-89-3,177795-59-4
rabeprazole

Guidance literature:: 2,3-dimethyl-4-(3-methoxy-propoxy)pyridine; With n-butyllithium; In tetrahydrofuran; at -90 - -80 ℃;

(-)-menthyl 2-benzimidazolylsulphinate; In tetrahydrofuran; at -80 - -20 ℃;

Reference yield: 88.0%

: 117977-21-6
rabeprazole sulfide

: 117976-89-3,177795-59-4
rabeprazole

Guidance literature:: With sodium hydroxide; dihydrogen peroxide; sodium tungstate; In methanol; water; at 20 ℃; for 0.666667h; Product distribution / selectivity;

Reference yield: 75.0%

: 117977-21-6
rabeprazole sulfide

: 117976-89-3,177795-59-4
rabeprazole

: 117976-47-3
LY 307640 sulfone

Guidance literature:: With sodium hydroxide; N-chloro-succinimide; water; In acetonitrile; at 0 - 5 ℃; for 2h; Product distribution / selectivity;