Cyclopropanecarboxylic acid, 2-[[[[(1R,2R)-2-(azidomethyl)cyclopropyl]carbonyl]amino]methyl]-, 2,3,4,5,6-pentafluorophenyl ester, (1R,2R)-

Base Information

Chemical Name:Cyclopropanecarboxylic acid, 2-[[[[(1R,2R)-2-(azidomethyl)cyclopropyl]carbonyl]amino]methyl]-, 2,3,4,5,6-pentafluorophenyl ester, (1R,2R)-
CAS No.:923273-04-5
Molecular Formula:C16H13F5N4O3
Molecular Weight:404.296
Hs Code.:

Cyclopropanecarboxylic acid,
2-[[[[(1R,2R)-2-(azidomethyl)cyclopropyl]carbonyl]amino]methyl]-,
2,3,4,5,6-pentafluorophenyl ester, (1R,2R)-

Synonyms:

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Chemical Property of Cyclopropanecarboxylic acid, 2-[[[[(1R,2R)-2-(azidomethyl)cyclopropyl]carbonyl]amino]methyl]-, 2,3,4,5,6-pentafluorophenyl ester, (1R,2R)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Cyclopropanecarboxylic acid, 2-[[[[(1R,2R)-2-(azidomethyl)cyclopropyl]carbonyl]amino]methyl]-, 2,3,4,5,6-pentafluorophenyl ester, (1R,2R)-

There total 8 articles about Cyclopropanecarboxylic acid, 2-[[[[(1R,2R)-2-(azidomethyl)cyclopropyl]carbonyl]amino]methyl]-, 2,3,4,5,6-pentafluorophenyl ester, (1R,2R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 923273-00-1
isopropyl (1R,2R)-2-{[(methylsulfonyl)oxy]methyl}cyclopropanecarboxylate

: 923273-04-5
pentafluorophenyl (1R,2R)-2-[({[(1R,2R)-2-(azidomethyl)cyclopropyl]carbonyl}amino)methyl]cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: 73 percent / sodium azide / dimethylformamide / 3 h / 95 °C

2: aq. sodium hydroxide / ethanol / 24 h / 20 °C

3: 985 mg / TBTU; diisopropylethylamine / CH₂Cl₂; dimethylformamide / 24 h / 20 °C

4: aq. sodium hydroxide / ethanol / 24 h / 20 °C

5: 135 mg / EDCI / CH₂Cl₂ / 0.5 h / sonication

With sodium hydroxide; sodium azide; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/b611882h

Reference yield:

: 923272-99-5
isopropyl (1R,2R)-2-[(benzyloxy)methyl]cyclopropanecarboxylate

: 923273-04-5
pentafluorophenyl (1R,2R)-2-[({[(1R,2R)-2-(azidomethyl)cyclopropyl]carbonyl}amino)methyl]cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: hydrogen / palladium on carbon / ethanol

2: 6.7 g / triethylamine / CH₂Cl₂ / 0.17 h / 0 °C

3: 73 percent / sodium azide / dimethylformamide / 3 h / 95 °C

4: aq. sodium hydroxide / ethanol / 24 h / 20 °C

5: 985 mg / TBTU; diisopropylethylamine / CH₂Cl₂; dimethylformamide / 24 h / 20 °C

6: aq. sodium hydroxide / ethanol / 24 h / 20 °C

7: 135 mg / EDCI / CH₂Cl₂ / 0.5 h / sonication

With sodium hydroxide; sodium azide; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/b611882h

Reference yield:

: 932026-74-9
isopropyl (1R,2R)-2-(hydroxymethyl)cyclopropanecarboxylate

: 923273-04-5
pentafluorophenyl (1R,2R)-2-[({[(1R,2R)-2-(azidomethyl)cyclopropyl]carbonyl}amino)methyl]cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: 6.7 g / triethylamine / CH₂Cl₂ / 0.17 h / 0 °C

2: 73 percent / sodium azide / dimethylformamide / 3 h / 95 °C

3: aq. sodium hydroxide / ethanol / 24 h / 20 °C

4: 985 mg / TBTU; diisopropylethylamine / CH₂Cl₂; dimethylformamide / 24 h / 20 °C

5: aq. sodium hydroxide / ethanol / 24 h / 20 °C

6: 135 mg / EDCI / CH₂Cl₂ / 0.5 h / sonication

With sodium hydroxide; sodium azide; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/b611882h