Technology Process of 3-Bromo-5-(4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl)-4-phenylpyridine
There total 6 articles about 3-Bromo-5-(4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl)-4-phenylpyridine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
3-bromo-5-(4,5-dihydro-4,4-dimethyloxazol-2-yl)pyridine;
With
lithium diisopropyl amide;
In
tetrahydrofuran;
at -78 ℃;
With
zinc(II) chloride;
In
tetrahydrofuran; diethyl ether;
at -78 - 20 ℃;
for 1h;
iodobenzene;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; diethyl ether;
for 20h;
Heating;
DOI:10.1021/ol062556i
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 70 percent / thionyl chloride / 16 h / 20 °C
2.1: lithium diisopropylamide / tetrahydrofuran / -78 °C
2.2: ZnCl2 / tetrahydrofuran; diethyl ether / 1 h / -78 - 20 °C
2.3: 90 percent / Pd(PPh3)4 / tetrahydrofuran; diethyl ether / 20 h / Heating
With
thionyl chloride; lithium diisopropyl amide;
In
tetrahydrofuran;
2.3: Negishi coupling;
DOI:10.1021/ol062556i
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 95 percent / zinc chloride / chlorobenzene / 48 h / Heating
2.1: lithium diisopropylamide / tetrahydrofuran / -78 °C
2.2: ZnCl2 / tetrahydrofuran; diethyl ether / 1 h / -78 - 20 °C
2.3: 90 percent / Pd(PPh3)4 / tetrahydrofuran; diethyl ether / 20 h / Heating
With
zinc(II) chloride; lithium diisopropyl amide;
In
tetrahydrofuran; chlorobenzene;
2.3: Negishi coupling;
DOI:10.1021/ol062556i
