Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[[2-methyl-2-(2 -nitrophenyl)-1-oxopropoxy]methyl]-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]

Base Information

Chemical Name:Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[[2-methyl-2-(2 -nitrophenyl)-1-oxopropoxy]methyl]-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
CAS No.:923291-12-7
Molecular Formula:C58H63N8O12P
Molecular Weight:1095.16
Hs Code.:

Adenosine,
N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[[2-methyl-2-(2
-nitrophenyl)-1-oxopropoxy]methyl]-, 3'-[2-cyanoethyl
N,N-bis(1-methylethyl)phosphoramidite]

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[[2-methyl-2-(2 -nitrophenyl)-1-oxopropoxy]methyl]-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]

Chemical Property:

Purity/Quality:

Safty Information:

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Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[[2-methyl-2-(2 -nitrophenyl)-1-oxopropoxy]methyl]-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]

There total 5 articles about Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[[2-methyl-2-(2 -nitrophenyl)-1-oxopropoxy]methyl]-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 923291-10-5
N⁶-benzoyl-5’-O-(4,4’-dimethoxytrityl)-2’-O-[[2-methyl-2-(2-nitrophenyl)-1-oxopropoxy]methyl]adenosine

: 124482-92-4,89992-70-1
2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

: 923291-12-7
N⁶-benzoyl-5’-O-(4,4’-dimethoxytrityl)-2’-O-[[2-methyl-2-(2-nitrophenyl)-1-oxopropoxy]methyl]adenosine-3’-O-(2-cyanoethyl-N,N-diisopropylphosphoramidite)

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 4h; Inert atmosphere;
DOI:10.1016/j.tetlet.2013.06.001

Reference yield:

: 1447969-80-3
N⁶-benzoyl-3’,5’-O-di-tert-butylsilyl-2’-O-[(methylthio)methyl]adenosine

: 923291-12-7
N⁶-benzoyl-5’-O-(4,4’-dimethoxytrityl)-2’-O-[[2-methyl-2-(2-nitrophenyl)-1-oxopropoxy]methyl]adenosine-3’-O-(2-cyanoethyl-N,N-diisopropylphosphoramidite)

Guidance literature:: Multi-step reaction with 4 steps

1: bromine; trimethylsilylacetylene; 18-crown-6 ether / 1,2-dichloro-ethane / 1 h / Cooling with ice; Inert atmosphere

2: triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 2 h / Inert atmosphere

3: pyridine / 20 °C / Inert atmosphere

4: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C / Inert atmosphere

With pyridine; 18-crown-6 ether; bromine; triethylamine tris(hydrogen fluoride); N-ethyl-N,N-diisopropylamine; trimethylsilylacetylene; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1016/j.tetlet.2013.06.001

Reference yield:

: 148692-01-7
N⁶-benzoyl-3’,5’-O-di-tert-butylsilyl adenosine

: 923291-12-7
N⁶-benzoyl-5’-O-(4,4’-dimethoxytrityl)-2’-O-[[2-methyl-2-(2-nitrophenyl)-1-oxopropoxy]methyl]adenosine-3’-O-(2-cyanoethyl-N,N-diisopropylphosphoramidite)

Guidance literature:: Multi-step reaction with 5 steps

1: acetic acid; acetic anhydride / 48 h / 20 °C

2: bromine; trimethylsilylacetylene; 18-crown-6 ether / 1,2-dichloro-ethane / 1 h / Cooling with ice; Inert atmosphere

3: triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 2 h / Inert atmosphere

4: pyridine / 20 °C / Inert atmosphere

5: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C / Inert atmosphere

With pyridine; 18-crown-6 ether; bromine; acetic anhydride; acetic acid; triethylamine tris(hydrogen fluoride); N-ethyl-N,N-diisopropylamine; trimethylsilylacetylene; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; 1: |Pummerer Sulfoxide Rearrangement;
DOI:10.1016/j.tetlet.2013.06.001