2-Propenal, 3-(1H-pyrrolo[2,3-b]pyridin-3-yl)-, (2E)-

Base Information

• Chemical Name: 2-Propenal, 3-(1H-pyrrolo[2,3-b]pyridin-3-yl)-, (2E)-
• CAS No.: 923293-12-3
• Molecular Formula: C₁₀H₈N₂O
• Molecular Weight: 172.186
• Mol file: 923293-12-3.mol

Synonyms:

Chemical Property of 2-Propenal, 3-(1H-pyrrolo[2,3-b]pyridin-3-yl)-, (2E)-

Chemical Property:

• PSA: 45.75000
• LogP: 1.77500

Purity/Quality:

99% ^*data from raw suppliers

(2E)-3-(1H-pyrrolo[2,3-b]pyridin-3-yl)-2-Propenal 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Propenal, 3-(1H-pyrrolo[2,3-b]pyridin-3-yl)-, (2E)-

There total 3 articles about 2-Propenal, 3-(1H-pyrrolo[2,3-b]pyridin-3-yl)-, (2E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

3-(3-Pyridyl)-2-aminopyridine → (E)-3-(1H-pyrrolo[2,3-b]pyridin-3-yl)-propenal (923293-12-3)

Guidance literature:

3-(3-Pyridyl)-2-aminopyridine; With bromocyane; In ethanol; at 70 ℃; for 0.333333h;

With water; ammonium chloride; In ethanol; at 70 ℃; for 2h;

DOI:10.1002/anie.200602996

Reference yield:

2-Amino-3-bromopyridine (13534-99-1) → (E)-3-(1H-pyrrolo[2,3-b]pyridin-3-yl)-propenal (923293-12-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 76 percent / Na₂CO₃ / trans-dichlorobis-(triphenylphosphine) palladium / dioxane; H₂O / 12 h / Heating

2.1: cyanogen bromide / ethanol / 0.33 h / 70 °C

2.2: 87 percent / NH₄Cl; H₂O / ethanol / 2 h / 70 °C

With bromocyane; sodium carbonate; trans-bis(triphenylphosphine)palladium dichloride; In 1,4-dioxane; ethanol; water; 1.1: Suzuki cross-coupling;

DOI:10.1002/anie.200602996

Reference yield:

3-pyridylboronic acid (1692-25-7) → (E)-3-(1H-pyrrolo[2,3-b]pyridin-3-yl)-propenal (923293-12-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 76 percent / Na₂CO₃ / trans-dichlorobis-(triphenylphosphine) palladium / dioxane; H₂O / 12 h / Heating

2.1: cyanogen bromide / ethanol / 0.33 h / 70 °C

2.2: 87 percent / NH₄Cl; H₂O / ethanol / 2 h / 70 °C

With bromocyane; sodium carbonate; trans-bis(triphenylphosphine)palladium dichloride; In 1,4-dioxane; ethanol; water; 1.1: Suzuki cross-coupling;

DOI:10.1002/anie.200602996

upstream raw materials:

2-Amino-3-bromopyridine

3-pyridylboronic acid