8-Aminoquinoline N-Oxide

Base Information

• Chemical Name: 8-Aminoquinoline N-Oxide
• CAS No.: 92339-84-9
• Molecular Formula: C₉H₈N₂O
• Molecular Weight: 160.175
• Hs Code.: 2933499090
• Mol file: 92339-84-9.mol

Synonyms:1-oxidoquinolin-1-ium-8-amine;

Chemical Property of 8-Aminoquinoline N-Oxide

Chemical Property:

• Vapor Pressure: 3.94E-06mmHg at 25°C
• Melting Point: 109.0 to 113.0 °C
• Boiling Point: 385oC at 760 mmHg
• PKA: 2.25±0.10(Predicted)
• Flash Point: 186.6oC
• PSA: 51.48000
• Density: 1.27g/cm3
• LogP: 2.43170

Purity/Quality:

98%,99%, ^*data from raw suppliers

8-Aminoquinoline N-Oxide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8-Aminoquinoline N-Oxide

There total 5 articles about 8-Aminoquinoline N-Oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

8-benzamidoquinoline N-oxide → 8-aminoquinoline-1-oxide (92339-84-9)

Guidance literature:

With sodium hydroxide; In ethanol; at 20 - 80 ℃; for 20h;

DOI:10.1021/acs.joc.0c01237

Reference yield: 84.0%

8-((4-methylphenyl)sulfonamido)-quinoline N-oxide (1620100-87-9) → 8-aminoquinoline-1-oxide (92339-84-9)

Guidance literature:

With sulfuric acid; at 0 - 20 ℃; for 2h;

DOI:10.1021/ja5053768

Reference yield:

Quinoline N-oxide (1613-37-2) → 8-aminoquinoline-1-oxide (92339-84-9)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid; Cp*Co(CO)I₂; silver hexafluoroantimonate / 12 h / 50 °C

2: sodium hydroxide / ethanol / 20 h / 20 - 80 °C

With silver hexafluoroantimonate; Cp*Co(CO)I₂; acetic acid; sodium hydroxide; In ethanol;

DOI:10.1021/acs.joc.0c01237

upstream raw materials:

8-((4-methylphenyl)sulfonamido)-quinoline N-oxide

Quinoline N-oxide

quinoline

Refernces

• 1、 Hwang, Heejun,Kim, Jinwoo,Jeong, Jisu,Chang, Sukbok. "Regioselective introduction of heteroatoms at the C-8 position of quinoline N-oxides: Remote C-H activation using N-oxide as a stepping stone". supporting information. p. 10770 - 10776. Retrieved 2014/08/18.