3-Pyridinecarboxylic acid, 2-[[(4R,5S)-3-[(1,1-dimethylethoxy)carbonyl]-4-[(2-fluorophenyl)methyl]- 2,2-dimethyl-5-oxazolidinyl]methyl]-, methyl ester

Base Information

Chemical Name:3-Pyridinecarboxylic acid, 2-[[(4R,5S)-3-[(1,1-dimethylethoxy)carbonyl]-4-[(2-fluorophenyl)methyl]- 2,2-dimethyl-5-oxazolidinyl]methyl]-, methyl ester
CAS No.:923563-68-2
Molecular Formula:C25H31FN2O5
Molecular Weight:458.53
Hs Code.:

3-Pyridinecarboxylic acid,
2-[[(4R,5S)-3-[(1,1-dimethylethoxy)carbonyl]-4-[(2-fluorophenyl)methyl]-
2,2-dimethyl-5-oxazolidinyl]methyl]-, methyl ester

Synonyms:

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Chemical Property of 3-Pyridinecarboxylic acid, 2-[[(4R,5S)-3-[(1,1-dimethylethoxy)carbonyl]-4-[(2-fluorophenyl)methyl]- 2,2-dimethyl-5-oxazolidinyl]methyl]-, methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 3-Pyridinecarboxylic acid, 2-[[(4R,5S)-3-[(1,1-dimethylethoxy)carbonyl]-4-[(2-fluorophenyl)methyl]- 2,2-dimethyl-5-oxazolidinyl]methyl]-, methyl ester

There total 4 articles about 3-Pyridinecarboxylic acid, 2-[[(4R,5S)-3-[(1,1-dimethylethoxy)carbonyl]-4-[(2-fluorophenyl)methyl]- 2,2-dimethyl-5-oxazolidinyl]methyl]-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-[3-tert-butoxycarbonyl-4-(2-fluoro-benzyl)-2,2-dimethyl-oxazolidin-5-ylmethyl]-nicotinic acid

: 18107-18-1
diazomethyl-trimethyl-silane

: 923563-68-2
2-[(4R,5S)-3-tert-butoxycarbonyl-4-(2-fluoro-benzyl)-2,2-dimethyl-oxazolidin-5-ylmethyl]-nicotinic acid methyl ester

Guidance literature:: In methanol; hexane; benzene; at 20 ℃; for 1h;

Reference yield:

: 923563-65-9
2-[3-tert-butoxycarbonylamino-4-(2-fluoro-phenyl)-2-oxo-butyl]-nicotinic acid

: 923563-68-2
2-[(4R,5S)-3-tert-butoxycarbonyl-4-(2-fluoro-benzyl)-2,2-dimethyl-oxazolidin-5-ylmethyl]-nicotinic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium tetrahydroborate / ethanol / 0.33 h / 0 °C

1.2: pH ~ 3

2.1: boron trifluoride diethyl etherate / 2,2-dimethoxy-propane; acetone / 0 - 40 °C

3.1: methanol; hexane; benzene / 1 h / 20 °C

With sodium tetrahydroborate; boron trifluoride diethyl etherate; In methanol; ethanol; hexane; 2,2-dimethoxy-propane; acetone; benzene;

Reference yield:

: 923563-66-0
2-[3-tert-butoxycarbonylamino-4-(2-fluoro-phenyl)-2-hydroxy-butyl]-nicotinic acid

: 923563-68-2
2-[(4R,5S)-3-tert-butoxycarbonyl-4-(2-fluoro-benzyl)-2,2-dimethyl-oxazolidin-5-ylmethyl]-nicotinic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: boron trifluoride diethyl etherate / 2,2-dimethoxy-propane; acetone / 0 - 40 °C

2: methanol; hexane; benzene / 1 h / 20 °C

With boron trifluoride diethyl etherate; In methanol; hexane; 2,2-dimethoxy-propane; acetone; benzene;