1-Piperidinecarboxylic acid, 3,4-dihydroxy-4-phenyl-, 1,1-dimethylethyl ester, (3R,4R)-

Base Information

Chemical Name:1-Piperidinecarboxylic acid, 3,4-dihydroxy-4-phenyl-, 1,1-dimethylethyl ester, (3R,4R)-
CAS No.:923948-71-4
Molecular Formula:C16H23NO4
Molecular Weight:293.363
Hs Code.:

Synonyms:

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Chemical Property of 1-Piperidinecarboxylic acid, 3,4-dihydroxy-4-phenyl-, 1,1-dimethylethyl ester, (3R,4R)-

Chemical Property:

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Technology Process of 1-Piperidinecarboxylic acid, 3,4-dihydroxy-4-phenyl-, 1,1-dimethylethyl ester, (3R,4R)-

There total 3 articles about 1-Piperidinecarboxylic acid, 3,4-dihydroxy-4-phenyl-, 1,1-dimethylethyl ester, (3R,4R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 186347-72-8
4-phenyl-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

: 923948-71-4
tert-butyl (3R,4R)-3,4-dihydroxy-4-phenyl-piperidine-1-carboxylate

Guidance literature:: 4-phenyl-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester; With AD-mix-β; methanesulfonamide; water; In tert-butyl alcohol; at 0 ℃; for 18h;

With sodium sulfite; In water; tert-butyl alcohol;

Reference yield:

: 108-86-1,52753-63-6
bromobenzene

: 923948-71-4
tert-butyl (3R,4R)-3,4-dihydroxy-4-phenyl-piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide; water / 1 h / 80 °C / Inert atmosphere

2: methanesulfonamide; AD-mix-β / water; tert-butyl alcohol / 8 h / 0 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; methanesulfonamide; AD-mix-β; sodium carbonate; In water; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 375853-82-0,286961-14-6
tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate

: 923948-71-4
tert-butyl (3R,4R)-3,4-dihydroxy-4-phenyl-piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide; water / 1 h / 80 °C / Inert atmosphere

2: methanesulfonamide; AD-mix-β / water; tert-butyl alcohol / 8 h / 0 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; methanesulfonamide; AD-mix-β; sodium carbonate; In water; N,N-dimethyl-formamide; tert-butyl alcohol;