Glycine, N-[(1S,2S)-2-[[(1,1-dimethylethoxy)carbonyl]amino]cyclopentyl]-N-[2-[2-[ (1,1-dimethylethyl)amino]-1,6-dihydro-6-oxo-7H-purin-7-yl]acetyl]-, phenylmethyl ester

Base Information

Chemical Name:Glycine, N-[(1S,2S)-2-[[(1,1-dimethylethoxy)carbonyl]amino]cyclopentyl]-N-[2-[2-[ (1,1-dimethylethyl)amino]-1,6-dihydro-6-oxo-7H-purin-7-yl]acetyl]-, phenylmethyl ester
CAS No.:923976-90-3
Molecular Formula:C30H41N7O6
Molecular Weight:609.682
Hs Code.:

Glycine,
N-[(1S,2S)-2-[[(1,1-dimethylethoxy)carbonyl]amino]cyclopentyl]-N-[2-[2-[
(1,1-dimethylethyl)amino]-1,6-dihydro-6-oxo-7H-purin-7-yl]acetyl]-,
phenylmethyl ester

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Glycine, N-[(1S,2S)-2-[[(1,1-dimethylethoxy)carbonyl]amino]cyclopentyl]-N-[2-[2-[ (1,1-dimethylethyl)amino]-1,6-dihydro-6-oxo-7H-purin-7-yl]acetyl]-, phenylmethyl ester

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Technology Process of Glycine, N-[(1S,2S)-2-[[(1,1-dimethylethoxy)carbonyl]amino]cyclopentyl]-N-[2-[2-[ (1,1-dimethylethyl)amino]-1,6-dihydro-6-oxo-7H-purin-7-yl]acetyl]-, phenylmethyl ester

There total 3 articles about Glycine, N-[(1S,2S)-2-[[(1,1-dimethylethoxy)carbonyl]amino]cyclopentyl]-N-[2-[2-[ (1,1-dimethylethyl)amino]-1,6-dihydro-6-oxo-7H-purin-7-yl]acetyl]-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 861114-49-0
N²-isobutyryl-7-(carboxymethyl)guanine

: 923976-87-8
tert-butyl (1S,2S)-2-((benzyloxycarbonyl)methylamino)cyclopentylcarbamate

: 923976-90-3
benzyl N-[(2S)-tert-butoxycarbonylaminocyclopent-(1S)-yl]-N-[[2-N-(isobutyryl)guanin-7-yl]acetyl]glycinate

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 17h;
DOI:10.1021/ja064317w

Reference yield:

: 586961-34-4,1193388-07-6,365996-21-0
(-)-(1S,2S)-N-mono(tert-butoxycarbonyl) cyclopentane-1,2-diamine

: 923976-90-3
benzyl N-[(2S)-tert-butoxycarbonylaminocyclopent-(1S)-yl]-N-[[2-N-(isobutyryl)guanin-7-yl]acetyl]glycinate

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / triethylamine / dimethylformamide / 4 h

2: 41 percent / 1-hydroxybenztriazole; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide / dimethylformamide / 17 h / 0 - 20 °C

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In N,N-dimethyl-formamide;
DOI:10.1021/ja064317w

Reference yield:

: 5437-45-6
Benzyl bromoacetate

: 923976-90-3
benzyl N-[(2S)-tert-butoxycarbonylaminocyclopent-(1S)-yl]-N-[[2-N-(isobutyryl)guanin-7-yl]acetyl]glycinate

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / triethylamine / dimethylformamide / 4 h

2: 41 percent / 1-hydroxybenztriazole; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide / dimethylformamide / 17 h / 0 - 20 °C

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In N,N-dimethyl-formamide;
DOI:10.1021/ja064317w