Propanedioic acid, 2-[(1Z)-2-(1-cyclohexen-1-yl)-2-[[tris(1-methylethyl)silyl]oxy]ethenyl]-2-(4- methyl-4-penten-2-yn-1-yl)-, 1,3-dimethyl ester

Base Information

Chemical Name:Propanedioic acid, 2-[(1Z)-2-(1-cyclohexen-1-yl)-2-[[tris(1-methylethyl)silyl]oxy]ethenyl]-2-(4- methyl-4-penten-2-yn-1-yl)-, 1,3-dimethyl ester
CAS No.:923987-55-7
Molecular Formula:C28H44O5Si
Molecular Weight:488.74
Hs Code.:

Propanedioic acid,
2-[(1Z)-2-(1-cyclohexen-1-yl)-2-[[tris(1-methylethyl)silyl]oxy]ethenyl]-2-(4-
methyl-4-penten-2-yn-1-yl)-, 1,3-dimethyl ester

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Propanedioic acid, 2-[(1Z)-2-(1-cyclohexen-1-yl)-2-[[tris(1-methylethyl)silyl]oxy]ethenyl]-2-(4- methyl-4-penten-2-yn-1-yl)-, 1,3-dimethyl ester

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Technology Process of Propanedioic acid, 2-[(1Z)-2-(1-cyclohexen-1-yl)-2-[[tris(1-methylethyl)silyl]oxy]ethenyl]-2-(4- methyl-4-penten-2-yn-1-yl)-, 1,3-dimethyl ester

There total 6 articles about Propanedioic acid, 2-[(1Z)-2-(1-cyclohexen-1-yl)-2-[[tris(1-methylethyl)silyl]oxy]ethenyl]-2-(4- methyl-4-penten-2-yn-1-yl)-, 1,3-dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 923987-65-9
dimethyl (4-methylpent-4-en-2-ynyl)[2-oxo-2-(cyclohex-1-enyl)ethyl]malonate

: 80522-42-5
triisopropylsilyl trifluoromethanesulfonate

: 923987-55-7
dimethyl (4-methylpent-4-en-2-ynyl)[(1Z)-2-(cyclohex-1-enyl)-2-(triisopropylsiloxy)ethenyl]malonate

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; at 20 ℃;
DOI:10.1021/ja0671924

Reference yield:

: 923987-61-5
dimethyl [2-oxo-2-(cyclohex-1-enyl)ethyl](prop-2-ynyl)malonate

: 923987-55-7
dimethyl (4-methylpent-4-en-2-ynyl)[(1Z)-2-(cyclohex-1-enyl)-2-(triisopropylsiloxy)ethenyl]malonate

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / Pd(PPh₃)4; CuI; triethylamine / dimethylformamide / 4 h / 50 °C

2: 23 percent / LDA / tetrahydrofuran / 20 °C

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/ja0671924

Reference yield:

: 54781-35-0
((1-(cyclohex-1-en-1-yl)vinyl)oxy)trimethylsilane

: 923987-55-7
dimethyl (4-methylpent-4-en-2-ynyl)[(1Z)-2-(cyclohex-1-enyl)-2-(triisopropylsiloxy)ethenyl]malonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-bromosuccinimide / tetrahydrofuran / -40 °C

2.1: NaH / tetrahydrofuran / 1.67 h / 0 °C

2.2: 59 percent / tetrahydrofuran

3.1: 86 percent / Pd(PPh₃)4; CuI; triethylamine / dimethylformamide / 4 h / 50 °C

4.1: 23 percent / LDA / tetrahydrofuran / 20 °C

With N-Bromosuccinimide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydride; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/ja0671924