ASISCHEM R41968

Base Information

• Chemical Name: ASISCHEM R41968
• CAS No.: 92407-86-8
• Molecular Formula: C17H14ClNO
• Molecular Weight: 283.757
• Hs Code.: 2933990090
• Mol file: 92407-86-8.mol

Synonyms:

Chemical Property of ASISCHEM R41968

Chemical Property:

• PSA: 22.00000
• LogP: 4.46390

Purity/Quality:

99% ^*data from raw suppliers

1-(4-Chlorobenzyl)-2-methyl-1H-indole-3-carbaldehyde 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ASISCHEM R41968

There total 3 articles about ASISCHEM R41968 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2-methyl-1H-indole-3-carbaldehyde (5416-80-8) → 1-(4-chlorobenzyl)-3-formyl-2-methyl-1H-indole (92407-86-8)

Guidance literature:

2-methyl-1H-indole-3-carbaldehyde; With sodium hydride; In acetonitrile; at 5 ℃; for 0.5h;

4-chlorobenzyl halide; In acetonitrile; at 20 ℃; for 12h;

DOI:10.1016/j.bmcl.2018.07.035

Reference yield: 80.0%

2-methyl-1H-indole-3-carbaldehyde (5416-80-8) + 1-Chloro-4-(chloromethyl)benzene (104-83-6) → 1-(4-chlorobenzyl)-3-formyl-2-methyl-1H-indole (92407-86-8)

Guidance literature:

With sodium hydride; In dimethyl sulfoxide; at 20 ℃; for 2h;

DOI:10.1016/S0223-5234(02)00005-3

Reference yield:

2-methyl-1H-indole (95-20-5) → 1-(4-chlorobenzyl)-3-formyl-2-methyl-1H-indole (92407-86-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: phosphorus oxychloride / 2 h / 5 - 20 °C

1.2: 90 percent / potassium hydroxide / H₂O

2.1: 80 percent / NaH / dimethylsulfoxide / 2 h / 20 °C

With sodium hydride; trichlorophosphate; In dimethyl sulfoxide; 1.1: Vilsmeier-Haack reaction;

DOI:10.1016/S0223-5234(02)00005-3

upstream raw materials:

2-methyl-1H-indole-3-carbaldehyde

1-Chloro-4-(chloromethyl)benzene

2-methyl-1H-indole

Downstream raw materials:

1-(4-chlorobenzyl)-3-hydroxymethyl-2-methyl-1H-indole

Refernces

• 1、 Na, Young-Min,Le Borgne, Marc,Pagniez, Fabrice,Le Baut, Guillaume,Le Pape, Patrice. "Synthesis and antifungal activity of new 1-halogenobenzyl-3-imidazolylmethylindole derivatives". . p. 75 - 87. Retrieved 2007/10/03.