L-Proline, (2S)-2-cyclohexyl-N-[[(2,2-dimethyl-4-penten-1-yl)oxy]carbonyl]glycyl-4-[ (7-bromo-6-methoxy-1-isoquinolinyl)oxy]-, ethyl ester, (4R)-

Base Information

• Chemical Name: L-Proline, (2S)-2-cyclohexyl-N-[[(2,2-dimethyl-4-penten-1-yl)oxy]carbonyl]glycyl-4-[ (7-bromo-6-methoxy-1-isoquinolinyl)oxy]-, ethyl ester, (4R)-
• CAS No.: 924271-88-5
• Molecular Formula: C33H44BrN3O7
• Molecular Weight: 674.632
• Mol file: 924271-88-5.mol

Synonyms:

Chemical Property of L-Proline, (2S)-2-cyclohexyl-N-[[(2,2-dimethyl-4-penten-1-yl)oxy]carbonyl]glycyl-4-[ (7-bromo-6-methoxy-1-isoquinolinyl)oxy]-, ethyl ester, (4R)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of L-Proline, (2S)-2-cyclohexyl-N-[[(2,2-dimethyl-4-penten-1-yl)oxy]carbonyl]glycyl-4-[ (7-bromo-6-methoxy-1-isoquinolinyl)oxy]-, ethyl ester, (4R)-

There total 2 articles about L-Proline, (2S)-2-cyclohexyl-N-[[(2,2-dimethyl-4-penten-1-yl)oxy]carbonyl]glycyl-4-[ (7-bromo-6-methoxy-1-isoquinolinyl)oxy]-, ethyl ester, (4R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2S)-cyclohexyl({[(2,2-dimethylpent-4-en-1-yl)oxy]carbonyl}amino)acetic acid (914841-18-2) + ethyl (4R)-4-[(7-bromo-6-methoxyisoquinolin-1-yl)oxy]-L-prolinate hydrochloride (924271-36-3) → ethyl (4R)-4-[(7-bromo-6-methoxyisoquinolin-1-yl)oxy]-1-[(2S)-2-cyclohexyl-2-({[(2,2-dimethylpent-4-en-1-yl)oxy]carbonyl}amino)acetyl]-L-prolinate (924271-88-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 6h;

Reference yield:

(2S)-cyclohexyl({[(2,2-dimethylpent-4-en-1-yl)oxy]carbonyl}amino)acetic acid (914841-18-2) + C17H19BrN2O4 (924365-09-3) → ethyl (4R)-4-[(7-bromo-6-methoxyisoquinolin-1-yl)oxy]-1-[(2S)-2-cyclohexyl-2-({[(2,2-dimethylpent-4-en-1-yl)oxy]carbonyl}amino)acetyl]-L-prolinate (924271-88-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide;

DOI:10.1021/ml1002426

Reference yield:

ethyl (4R)-4-[(7-bromo-6-methoxyisoquinolin-1-yl)oxy]-1-[(2S)-2-cyclohexyl-2-({[(2,2-dimethylpent-4-en-1-yl)oxy]carbonyl}amino)acetyl]-L-prolinate (924271-88-5) + tri-n-butyl(vinyl)tin (7486-35-3) → ethyl (4R)-1-[(2S)-2-cyclohexyl-2-({[(2,2-dimethylpent-4-en-1-yl)oxy]carbonyl}amino)acetyl]-4-[(6-methoxy-7-vinylisoquinolin-1-yl)oxy]-L-prolinate (1021435-04-0)

Guidance literature:

tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; at 20 - 105 ℃; for 21h;

upstream raw materials:

(2S)-cyclohexyl({[(2,2-dimethylpent-4-en-1-yl)oxy]carbonyl}amino)acetic acid

ethyl (4R)-4-[(7-bromo-6-methoxyisoquinolin-1-yl)oxy]-L-prolinate hydrochloride

C₁₇H₁₉BrN₂O₄

Downstream raw materials:

ethyl (4R)-1-[(2S)-2-cyclohexyl-2-({[(2,2-dimethylpent-4-en-1-yl)oxy]carbonyl}amino)acetyl]-4-[(6-methoxy-7-vinylisoquinolin-1-yl)oxy]-L-prolinate

C₄₀H₅₃N₅O₉S

(3R,5S,8S)-8-cyclohexyl-18-methoxy-13,13-dimethyl-7,10-dioxo-2,11-dioxa-6,9,23-triazatetracyclo[15.6.2.1~3,6~.0~20,24~]hexacosa-1⁽²³⁾,17,19,21,24-pentaene-5-carboxylic acid

ethyl (2R,4S,7S)-7-cyclohexyl-23-methoxy-12,12-dimethyl-6,9-dioxo-3,4,6,7,8,9,12,13,14,15-decahydro-2H,11H-16,18-(ethanediylidene)-2,5-methanopyrido[2,3-k][1,10,3,6]dioxadiazacyclononadecine-4-carboxylate