2-Pyridinecarboxylic acid, 4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1,2,3,6-tetrahydro-1-(phenylmeth yl)-6-(3,4,5-trimethoxyphenyl)-, ethyl ester

Base Information

• Chemical Name: 2-Pyridinecarboxylic acid, 4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1,2,3,6-tetrahydro-1-(phenylmeth yl)-6-(3,4,5-trimethoxyphenyl)-, ethyl ester
• CAS No.: 924294-68-8
• Molecular Formula: C30H43NO6Si
• Molecular Weight: 541.76
• Mol file: 924294-68-8.mol

Synonyms:

Chemical Property of 2-Pyridinecarboxylic acid, 4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1,2,3,6-tetrahydro-1-(phenylmeth yl)-6-(3,4,5-trimethoxyphenyl)-, ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Pyridinecarboxylic acid, 4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1,2,3,6-tetrahydro-1-(phenylmeth yl)-6-(3,4,5-trimethoxyphenyl)-, ethyl ester

There total 1 articles about 2-Pyridinecarboxylic acid, 4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1,2,3,6-tetrahydro-1-(phenylmeth yl)-6-(3,4,5-trimethoxyphenyl)-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2-(benzylimino)acetate (64222-28-2) + (E)-3-tert-butyldimethylsiloxy-1-(3,4,5-trimethoxyphenyl)-1,3-butadiene (196957-42-3) → 1-benzyl-4-(tert-butyl-dimethyl-silanyloxy)-6-(3,4,5-trimethoxy-phenyl)-1,2,3,6-tetrahydro-pyridine-2-carboxylic acid ethyl ester (924294-68-8)

Guidance literature:

With zinc(II) chloride; In dichloromethane; Heating;

DOI:10.3390/11110929

Reference yield: 60.0%

1-benzyl-4-(tert-butyl-dimethyl-silanyloxy)-6-(3,4,5-trimethoxy-phenyl)-1,2,3,6-tetrahydro-pyridine-2-carboxylic acid ethyl ester (924294-68-8) → (E)-6-(3,4,5-trimethoxystyryl)-4-(benzylamino)-4,5-dihydropyridazin-3(2H)-one

Guidance literature:

With boron trifluoride diethyl etherate; hydrazine hydrate; In ethanol; for 3h; Heating;

DOI:10.3390/11110929

Reference yield: 41.0%

1-benzyl-4-(tert-butyl-dimethyl-silanyloxy)-6-(3,4,5-trimethoxy-phenyl)-1,2,3,6-tetrahydro-pyridine-2-carboxylic acid ethyl ester (924294-68-8) → 3-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-1H-pyrazol-3-yl]-acrylic acid ethyl ester + 6-(3,4,5-trimethoxy-α-styryl)pyridazin-3(2H)-one (924294-74-6)

Guidance literature:

With boron trifluoride diethyl etherate; hydrazine hydrate; acetic acid; for 24h; Heating;

DOI:10.3390/11110929

upstream raw materials:

ethyl 2-(benzylimino)acetate

(E)-3-tert-butyldimethylsiloxy-1-(3,4,5-trimethoxyphenyl)-1,3-butadiene

Downstream raw materials:

6-(3,4,5-trimethoxy-α-styryl)pyridazin-3(2H)-one