1,1-Cyclohexanedicarboxylic acid, 4-hydroxy-, dimethyl ester

Base Information

Chemical Name:1,1-Cyclohexanedicarboxylic acid, 4-hydroxy-, dimethyl ester
CAS No.:92454-01-8
Molecular Formula:C10H16O5
Molecular Weight:216.234
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1,1-Cyclohexanedicarboxylic acid, 4-hydroxy-, dimethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1,1-Cyclohexanedicarboxylic acid, 4-hydroxy-, dimethyl ester

There total 11 articles about 1,1-Cyclohexanedicarboxylic acid, 4-hydroxy-, dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 58774-03-1
4-oxo-cyclohexane-1,1-dicarboxylic acid dimethyl ester

: 92454-01-8
dimethyl 4-hydroxycyclohexane-1,1-dicarboxylate

Guidance literature:: With sodium tetrahydroborate; In methanol; at 0 ℃; for 4h;

Reference yield:

: 7250-55-7
dimethyl 3-hydroxypentanedioate

: 92454-01-8
dimethyl 4-hydroxycyclohexane-1,1-dicarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: 1H-imidazole

2: lithium aluminium tetrahydride

3: triethylamine / dichloromethane / 2 h / -10 - 0 °C

4: lithium tert-butoxide / toluene / 0 °C / Inert atmosphere; Reflux

5: potassium hydrogen difluoride; tetrabutyl ammonium fluoride / acetonitrile; tetrahydrofuran; water / 29 h / Reflux

With 1H-imidazole; lithium aluminium tetrahydride; potassium hydrogen difluoride; tetrabutyl ammonium fluoride; triethylamine; lithium tert-butoxide; In tetrahydrofuran; dichloromethane; water; toluene; acetonitrile;
DOI:10.1039/c6ra01548d

Reference yield:

: 3-(tert-butyldimethylsilyloxy)pentane-1,5-diyldimethanesulfonate

: 92454-01-8
dimethyl 4-hydroxycyclohexane-1,1-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: lithium tert-butoxide / toluene / 0 °C / Inert atmosphere; Reflux

2: potassium hydrogen difluoride; tetrabutyl ammonium fluoride / acetonitrile; tetrahydrofuran; water / 29 h / Reflux

With potassium hydrogen difluoride; tetrabutyl ammonium fluoride; lithium tert-butoxide; In tetrahydrofuran; water; toluene; acetonitrile;
DOI:10.1039/c6ra01548d