(9bR)-9b-(3,5-dimethylphenyl)-2,3-dihydro[1,3]thiazolo[2,3-a]isoindol-5(9bH)-one

Base Information

• Chemical Name: (9bR)-9b-(3,5-dimethylphenyl)-2,3-dihydro[1,3]thiazolo[2,3-a]isoindol-5(9bH)-one
• CAS No.: 143390-74-3
• Molecular Formula: C₁₈H₁₇NOS
• Molecular Weight: 295.405
• Mol file: 143390-74-3.mol

Synonyms:Thiazolo[2,3-a]isoindol-5(9bH)-one,9b-(3,5-dimethylphenyl)-2,3-dihydro-, (R)-; BM 51.0836; BM 510836

Chemical Property of (9bR)-9b-(3,5-dimethylphenyl)-2,3-dihydro[1,3]thiazolo[2,3-a]isoindol-5(9bH)-one

Chemical Property:

• Vapor Pressure: 2.67E-09mmHg at 25°C
• Boiling Point: 478°Cat760mmHg
• Flash Point: 242.9°C
• PSA: 0.00000
• Density: 1.29g/cm³
• LogP: 0.00000

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (9bR)-9b-(3,5-dimethylphenyl)-2,3-dihydro[1,3]thiazolo[2,3-a]isoindol-5(9bH)-one

There total 3 articles about (9bR)-9b-(3,5-dimethylphenyl)-2,3-dihydro[1,3]thiazolo[2,3-a]isoindol-5(9bH)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

2-(3,5-dimethylbenzoyl)benzoic acid (149817-31-2) + Cysteamine (60-23-1) → 9b-(3,5-dimethylphenyl)2,3-dihydrothiazolo[2,3-a]-isoindol-5(9bH)-one (143390-74-3)

Guidance literature:

With toluene-4-sulfonic acid; In toluene; Heating;

DOI:10.1021/jm00069a011

Reference yield:

2-(3,5-dimethylbenzoyl)benzoic acid (149817-31-2) → (R)-9b-(3,5-Dimethyl-phenyl)-2,3-dihydro-9bH-thiazolo[2,3-a]isoindol-5-one (143390-74-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 76 percent / toluene 4-sulfonic acid / toluene / Heating

With toluene-4-sulfonic acid; In toluene;

DOI:10.1021/jm00069a011

Reference yield:

9b-(3,5-dimethylphenyl)2,3-dihydrothiazolo[2,3-a]-isoindol-5(9bH)-one (143390-74-3) → (R)-9b-(3,5-Dimethyl-phenyl)-2,3-dihydro-9bH-thiazolo[2,3-a]isoindol-5-one (143390-74-3)

Guidance literature:

DOI:10.1021/jm00069a011

upstream raw materials:

2-(3,5-dimethylbenzoyl)benzoic acid

Cysteamine