16,19-Dihydroxy-4-androsten-3,17-dione

Base Information

Chemical Name:16,19-Dihydroxy-4-androsten-3,17-dione
CAS No.:60385-81-1
Molecular Formula:C₁₉H₂₆O₄
Molecular Weight:318.413
Hs Code.:
DSSTox Substance ID:DTXSID70975791
Nikkaji Number:J1.559.524H
Wikidata:Q82960484
Mol file:60385-81-1.mol

Synonyms:16,19-DHAD;16,19-dihydroxy-4-androsten-3,17-dione;16,19-dihydroxyandrost-4-ene-3,17,-dione;16alpha,19-dihydroxy-4-androstene-3,17-dione;16alpha,19-dihydroxyandrostenedione

Suppliers and Price of 16,19-Dihydroxy-4-androsten-3,17-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 16,19-Dihydroxy-4-androsten-3,17-dione

Chemical Property:

Vapor Pressure:1.73E-13mmHg at 25°C
Melting Point:189 - 190 °C (acetone)
Boiling Point:530.9°C at 760 mmHg
PKA:13.02±0.60(Predicted)
Flash Point:289°C
PSA：74.60000
Density:1.26g/cm³
LogP:2.03060
XLogP3:1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:318.18310931
Heavy Atom Count:23
Complexity:594

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC12CCC3C(C1CC(C2=O)O)CCC4=CC(=O)CCC34CO
Isomeric SMILES:C[C@]12CC[C@H]3[C@H]([C@@H]1C[C@H](C2=O)O)CCC4=CC(=O)CC[C@]34CO

Technology Process of 16,19-Dihydroxy-4-androsten-3,17-dione

There total 5 articles about 16,19-Dihydroxy-4-androsten-3,17-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 116535-62-7
16α-hydroxy-6β,19-epoxyandrost-4-ene-3,17-dione

: 60385-81-1
16α,19-dihydroxy-4-androstene-3,17-dione

Guidance literature:: With zinc; In ethanol; acetic acid; for 4h; Heating;
DOI:10.1016/0039-128X(87)90002-X

Reference yield:

: 7745-16-6
5α-bromo-3β-hydroxy-6β,19-epoxyandrostan-17-one

: 60385-81-1
16α,19-dihydroxy-4-androstene-3,17-dione

Guidance literature:: Multi-step reaction with 4 steps

1: 84 percent / CuBr₂ / methanol / 7 h / Heating

2: 95 percent Chromat_. / 8 N CrO₃ / acetone

3: 1 N NaOH / pyridine; H₂O / Ambient temperature

4: 60 percent / zink dust / ethanol; acetic acid / 4 h / Heating

With chromium(VI) oxide; sodium hydroxide; copper(ll) bromide; zinc; In pyridine; methanol; ethanol; water; acetic acid; acetone;
DOI:10.1016/0039-128X(87)90002-X

Reference yield:

: 99714-90-6
5α,16α-dibromo-3β-hydroxy-6β,19-epoxyandrostan-17-one

: 60385-81-1
16α,19-dihydroxy-4-androstene-3,17-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent Chromat_. / 8 N CrO₃ / acetone

2: 1 N NaOH / pyridine; H₂O / Ambient temperature

3: 60 percent / zink dust / ethanol; acetic acid / 4 h / Heating

With chromium(VI) oxide; sodium hydroxide; zinc; In pyridine; ethanol; water; acetic acid; acetone;
DOI:10.1016/0039-128X(87)90002-X