Technology Process of 2-Heptenoic acid, 6-(3-methoxy-4-methylphenyl)-2-methyl-, ethyl ester,
(2Z,6R)-
There total 5 articles about 2-Heptenoic acid, 6-(3-methoxy-4-methylphenyl)-2-methyl-, ethyl ester,
(2Z,6R)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(R)-2-methoxy-1-methyl-4-(6-methylhept-5-en-2-yl)benzene;
With
N-methyl-2-indolinone;
osmium(VIII) oxide;
In
water; acetone;
at 20 ℃;
for 24h;
With
sodium periodate;
In
dichloromethane;
at 20 ℃;
for 5h;
ethyl 2-((bis(o-tolyloxy))phosphoryl)propanoate;
With
sodium hydride;
In
tetrahydrofuran;
at -78 ℃;
for 3h;
DOI:10.1016/j.tetlet.2006.11.135
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 95 percent / tetrahydrofuran / 0 - 20 °C
2.1: oxalyl chloride; DMSO; Et3N / CH2Cl2 / 5.5 h / -78 - 20 °C
2.2: MeSO2Cl; Et3N / CH2Cl2 / 0 deg C to rt then reflux 7 h
2.3: 47 percent / KOH / methanol / 7 h / Heating
3.1: 90 percent / K2CO3 / acetone / 12 h / Heating
4.1: NMO / OsO4 / H2O; acetone / 24 h / 20 °C
4.2: NaIO4 on silica gel / CH2Cl2 / 5 h / 20 °C
4.3: 85 percent / NaH / tetrahydrofuran / 3 h / -78 °C
With
N-methyl-2-indolinone; oxalyl dichloride; potassium carbonate; dimethyl sulfoxide; triethylamine;
osmium(VIII) oxide;
In
tetrahydrofuran; dichloromethane; water; acetone;
2.1: Swern oxidation;
DOI:10.1016/j.tetlet.2006.11.135
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: oxalyl chloride; DMSO; Et3N / CH2Cl2 / 5.5 h / -78 - 20 °C
1.2: MeSO2Cl; Et3N / CH2Cl2 / 0 deg C to rt then reflux 7 h
1.3: 47 percent / KOH / methanol / 7 h / Heating
2.1: 90 percent / K2CO3 / acetone / 12 h / Heating
3.1: NMO / OsO4 / H2O; acetone / 24 h / 20 °C
3.2: NaIO4 on silica gel / CH2Cl2 / 5 h / 20 °C
3.3: 85 percent / NaH / tetrahydrofuran / 3 h / -78 °C
With
N-methyl-2-indolinone; oxalyl dichloride; potassium carbonate; dimethyl sulfoxide; triethylamine;
osmium(VIII) oxide;
In
dichloromethane; water; acetone;
1.1: Swern oxidation;
DOI:10.1016/j.tetlet.2006.11.135
