L-Proline, 3-hydroxy-1-[(4-methoxyphenyl)methyl]-3-methyl-4-[(methylamino)methyl ]-5-oxo-2-[(phenylmethoxy)methyl]-, methyl ester, (3S,4R)-

Base Information

• Chemical Name: L-Proline, 3-hydroxy-1-[(4-methoxyphenyl)methyl]-3-methyl-4-[(methylamino)methyl ]-5-oxo-2-[(phenylmethoxy)methyl]-, methyl ester, (3S,4R)-
• CAS No.: 924888-96-0
• Molecular Formula: C₂₅H₃₂N₂O₆
• Molecular Weight: 456.539
• Mol file: 924888-96-0.mol

Synonyms:

Chemical Property of L-Proline, 3-hydroxy-1-[(4-methoxyphenyl)methyl]-3-methyl-4-[(methylamino)methyl ]-5-oxo-2-[(phenylmethoxy)methyl]-, methyl ester, (3S,4R)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of L-Proline, 3-hydroxy-1-[(4-methoxyphenyl)methyl]-3-methyl-4-[(methylamino)methyl ]-5-oxo-2-[(phenylmethoxy)methyl]-, methyl ester, (3S,4R)-

There total 4 articles about L-Proline, 3-hydroxy-1-[(4-methoxyphenyl)methyl]-3-methyl-4-[(methylamino)methyl ]-5-oxo-2-[(phenylmethoxy)methyl]-, methyl ester, (3S,4R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-benzyloxymethyl-5-(4-methoxy-benzyl)-2,6a-dimethyl-4-oxo-hexahydro-pyrrolo[3,4-d]isoxazole-6-carboxylic acid methyl ester (924888-94-8) → 2-benzyloxymethyl-3-hydroxy-1-(4-methoxy-benzyl)-3-methyl-4-methylaminomethyl-5-oxo-pyrrolidine-2-carboxylic acid methyl ester (924888-96-0)

Guidance literature:

With hydrogen; palladium dihydroxide; In methanol; ethyl acetate;

DOI:10.1016/j.tetlet.2006.11.087

Reference yield:

2-benzyloxymethyl-3-methyl-5-oxo-2,5-dihydro-1H-pyrrole-2-carboxylic acid methyl ester → 2-benzyloxymethyl-3-hydroxy-1-(4-methoxy-benzyl)-3-methyl-4-methylaminomethyl-5-oxo-pyrrolidine-2-carboxylic acid methyl ester (924888-96-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: Cs₂CO₃ / dimethylformamide

2.1: H₂O₂

2.2: toluene / Heating

3.1: H₂ / Pd(OH)2 / ethyl acetate; methanol

With hydrogen; dihydrogen peroxide; caesium carbonate; palladium dihydroxide; In methanol; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1016/j.tetlet.2006.11.087

Reference yield:

2-benzyloxymethyl-1-(4-methoxy-benzyl)-3-methyl-5-oxo-2,5-dihydro-1H-pyrrole-2-carboxylic acid methyl ester (924888-93-7) → 2-benzyloxymethyl-3-hydroxy-1-(4-methoxy-benzyl)-3-methyl-4-methylaminomethyl-5-oxo-pyrrolidine-2-carboxylic acid methyl ester (924888-96-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: H₂O₂

1.2: toluene / Heating

2.1: H₂ / Pd(OH)2 / ethyl acetate; methanol

With hydrogen; dihydrogen peroxide; palladium dihydroxide; In methanol; ethyl acetate;

DOI:10.1016/j.tetlet.2006.11.087

upstream raw materials:

6-benzyloxymethyl-5-(4-methoxy-benzyl)-2,6a-dimethyl-4-oxo-hexahydro-pyrrolo[3,4-d]isoxazole-6-carboxylic acid methyl ester

2-benzyloxymethyl-1-(4-methoxy-benzyl)-3-methyl-5-oxo-2,5-dihydro-1H-pyrrole-2-carboxylic acid methyl ester

p-Methoxybenzyl bromide

Downstream raw materials:

methyl (2R,3S)-1-(4-methoxybenzyl)-2-((benzyloxy)methyl)-3-hydroxy-3-methyl-4-methylene-5-oxopyrrolidine-2-carboxaldehyde