1H-Pyrazolo[3,4-b]pyridin-4-ol, 1-[(4-methoxyphenyl)methyl]-

Base Information

• Chemical Name: 1H-Pyrazolo[3,4-b]pyridin-4-ol, 1-[(4-methoxyphenyl)methyl]-
• CAS No.: 924909-16-0
• Molecular Formula: C₁₄H₁₃N₃O₂
• Molecular Weight: 255.276
• Mol file: 924909-16-0.mol

Synonyms:1-(4-Methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-4-ol;1-(4-METHOXYBENZYL)-1H-PYRAZOLO-[3,4-B]PYRIDIN-4-OL;

Chemical Property of 1H-Pyrazolo[3,4-b]pyridin-4-ol, 1-[(4-methoxyphenyl)methyl]-

Chemical Property:

• Boiling Point: 480.2±40.0 °C (760 mmHg)
• PSA: 60.17000
• Density: 1.30±0.1 g/cm3 (20 °C, 760 mmHg)
• LogP: 2.19380

Purity/Quality:

97% ^*data from raw suppliers

1-(4-Methoxy-benzyl)-1H-pyrazolo[3,4-b]pyridin-4-ol 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Pyrazolo[3,4-b]pyridin-4-ol, 1-[(4-methoxyphenyl)methyl]-

There total 10 articles about 1H-Pyrazolo[3,4-b]pyridin-4-ol, 1-[(4-methoxyphenyl)methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-Hydroxy-1-[(4-methoxyphenyl)methyl]-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid (370865-99-9) → 1-(4-methoxy-benzyl)-1,7-dihydro-pyrazolo[3,4-b]pyridin-4-one (924909-16-0,370866-00-5)

Guidance literature:

at 230 ℃; for 0.25h;

DOI:10.1016/S0960-894X(03)00381-0

Reference yield: 91.0%

5-(((1-(4-methoxybenzyl)-1H-pyrazol-5-yl)amino)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione (949556-46-1) → 1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-4-ol (924909-16-0,370866-00-5)

Guidance literature:

With dowtherm A; at 240 ℃; for 0.333333h;

Reference yield: 35.0%

4-Hydroxy-1-[(4-methoxyphenyl)methyl]-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid (370865-99-9) → 1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-4-ol (924909-16-0,370866-00-5)

Guidance literature:

4-hydroxy-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid; copper (II) carbonate hydroxide; In 1,3-dimethyl-2-imidazolidinone; at 180 ℃; for 3h;

With water; In 1,3-dimethyl-2-imidazolidinone;

upstream raw materials:

4-Hydroxy-1-[(4-methoxyphenyl)methyl]-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid

1-(4-methoxybenzyl)-1H-pyrazol-5-amine

4-Hydroxy-1-[(4-methoxyphenyl)methyl]-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester

5-(((1-(4-methoxybenzyl)-1H-pyrazol-5-yl)amino)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione

Downstream raw materials:

4-(2-fluoro-4-nitrophenoxy)-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridine

1-(4-methoxybenzyl)-4-(5-chloro-2-methyl-4-nitrophenoxy)-1H-pyrazolo[3,4-b]pyridine

4-chloro-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridine

4-Chloro-1H-pyrazolo<3,4-b>pyridine