1-[(1S,2R,3S)-2-fluoro-3-(hydroxymethyl)cyclopentyl]-5-methylpyrimidine-2,4(1H,3H)-dione

Base Information

Chemical Name:1-[(1S,2R,3S)-2-fluoro-3-(hydroxymethyl)cyclopentyl]-5-methylpyrimidine-2,4(1H,3H)-dione
CAS No.:129829-85-2
Molecular Formula:C₁₁H₁₅FN₂O₃
Molecular Weight:242.25
Hs Code.:

Synonyms:2,4(1H,3H)-Pyrimidinedione,1-[2-fluoro-3-(hydroxymethyl)cyclopentyl]-5-methyl-, (1a,2a,3a)- (9CI); 2,4(1H,3H)-Pyrimidinedione,1-[2-fluoro-3-(hydroxymethyl)cyclopentyl]-5-methyl-, (1a,2a,3a)-(?à)-

Suppliers and Price of 1-[(1S,2R,3S)-2-fluoro-3-(hydroxymethyl)cyclopentyl]-5-methylpyrimidine-2,4(1H,3H)-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 1-[(1S,2R,3S)-2-fluoro-3-(hydroxymethyl)cyclopentyl]-5-methylpyrimidine-2,4(1H,3H)-dione

Chemical Property:

Boiling Point:°Cat760mmHg
Flash Point:°C
Density:1.35g/cm³

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1-[(1S,2R,3S)-2-fluoro-3-(hydroxymethyl)cyclopentyl]-5-methylpyrimidine-2,4(1H,3H)-dione

There total 22 articles about 1-[(1S,2R,3S)-2-fluoro-3-(hydroxymethyl)cyclopentyl]-5-methylpyrimidine-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 137709-65-0
N-<(1'β,4'β,6'α)-6'-fluoro-4'-(hydroxymethyl)cyclopentylaminocarbonyl>-3-methoxy-2-methylprop-2-enamide

: 127530-14-7,129829-85-2,129829-86-3
(1'β,4'β,6'α)-1-<6'-fluoro-4'-(hydroxymethyl)cyclopentyl>-5-methylpyrimidine-2,4(1H,3H)-dione

Guidance literature:: With hydrogenchloride; for 0.5h; Heating;

Reference yield:

: 119895-90-8
triphenylmethoxymethylcyclopent-2-ene

: 127530-14-7,129829-85-2,129829-86-3
(1'β,4'β,6'α)-1-<6'-fluoro-4'-(hydroxymethyl)cyclopentyl>-5-methylpyrimidine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 7 steps

1: 1) dibromodimethylhydantoin, 2) potassium carbonate / 1) acetone, water, 0 deg C, 2) methanol, room temperature, overnight

2: 84 percent / sodium azide, ammonium chloride / aq. ethanol / 72 h / 100 °C

3: 21 percent / diethylaminosulphur trifluoride / CH₂Cl₂ / 0.17 h / 0 °C

4: 99 percent / H₂ / Lindlar / ethanol / 3 h / 760 Torr / Ambient temperature

5: 82 percent / dimethylformamide / Ambient temperature; overnight

6: 89 percent / p-toluenesulphonic acid / CH₂Cl₂; methanol / 3 h / Ambient temperature

7: 88 percent / aq. hydrochloric acid / 0.5 h / Heating

With hydrogenchloride; sodium azide; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; diethylamino-sulfur trifluoride; ammonium chloride; hydrogen; potassium carbonate; toluene-4-sulfonic acid; Lindlar's catalyst; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 119895-91-9,129829-81-8,129829-82-9,137767-65-8,137767-66-9
2-exo-triphenylmethoxymethyl-6-oxabicyclo<3.1.0>hexane

: 127530-14-7,129829-85-2,129829-86-3
(1'β,4'β,6'α)-1-<6'-fluoro-4'-(hydroxymethyl)cyclopentyl>-5-methylpyrimidine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 6 steps

1: 84 percent / sodium azide, ammonium chloride / aq. ethanol / 72 h / 100 °C

2: 21 percent / diethylaminosulphur trifluoride / CH₂Cl₂ / 0.17 h / 0 °C

3: 99 percent / H₂ / Lindlar / ethanol / 3 h / 760 Torr / Ambient temperature

4: 82 percent / dimethylformamide / Ambient temperature; overnight

5: 89 percent / p-toluenesulphonic acid / CH₂Cl₂; methanol / 3 h / Ambient temperature

6: 88 percent / aq. hydrochloric acid / 0.5 h / Heating

With hydrogenchloride; sodium azide; diethylamino-sulfur trifluoride; ammonium chloride; hydrogen; toluene-4-sulfonic acid; Lindlar's catalyst; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;