FR148083;L783279;LL-Z 1640-2

Base Information

• Chemical Name: FR148083;L783279;LL-Z 1640-2
• CAS No.: 253863-19-3
• Molecular Formula: C19H22O7
• Molecular Weight: 362.4
• Hs Code.: 3507909090
• European Community (EC) Number: 683-694-3
• Wikidata: Q104172412
• Mol file: 253863-19-3.mol

Synonyms:8,9,16-trihydroxy-14-methoxy-3-methyl-3,4,9,10-tetrahydro-1H-benzo(c)(1)oxacyclotetradecine-1,7(8H)-dione;f152A1 compound;FR 148083;FR-148083;FR148083;LL Z1640-2;LL-Z1640-2

Chemical Property of FR148083;L783279;LL-Z 1640-2

Chemical Property:

• Appearance/Colour: White to off-white solid
• Melting Point: 171-173 °C(Solv: dichloromethane (75-09-2); hexane (110-54-3))
• Boiling Point: 666.8°Cat760mmHg
• PKA: 7.32±0.70(Predicted)
• Flash Point: 240.2°C
• PSA: 113.29000
• Density: 1.27g/cm³
• LogP: 1.60020
• Storage Temp.: 2-8°C
• Solubility.: DMSO: >10mg/mL
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 1
• Exact Mass: 362.13655304
• Heavy Atom Count: 26
• Complexity: 556

Purity/Quality:

99% ^*data from raw suppliers

(5Z)-7-Oxozeaenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1CC=CC(=O)C(C(CC=CC2=C(C(=CC(=C2)OC)O)C(=O)O1)O)O
• Uses: LL Z1640-2 (5Z-7-oxozeaenol) is a cis-enone resorcylic acid lactone first reported in 1978 and later rediscovered as an irreversible and highly selective TAK 1 inhibitor. TAK1 is a MAPKKK involved in the p38 signalling cascade for pro-inflammation signals such as cytokines. LL Z1640-2 effectively prevents inflammation in animal models. (5Z)-7-Oxozeaenol is a highly potent inhibitor of TAK1, which is a member of the mitogen-acitvated kinase kinase kinase (MAPKKK) family. 5Z-?7-?Oxozeaenol blocked interleukin-?1-?induced activation of TAK1, JNK?/p38 MAPK, IκB kinases, and NF-?κB, resulting in inhibition of cyclooxgenase-?2 production.

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