Technology Process of Asperlicin E
There total 11 articles about Asperlicin E which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(7S)-6,7-dihydro-7-(1H-indol-3-ylmethyl)quinazolino[3,2-a][1,4]benzodiazepine-5,13-dione;
With
3,3-dimethyldioxirane;
In
tetrahydrofuran; acetone;
at -78 ℃;
for 0.5h;
Green chemistry;
With
sodium carbonate;
In
tetrahydrofuran; water; acetone;
at 23 ℃;
for 5h;
Green chemistry;
DOI:10.1016/j.tetlet.2015.01.084
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: triethylamine / water / 5 h / 23 °C
1.2: Reflux
2.1: triethylamine; dmap / tetrahydrofuran / 0.25 h / 23 °C
2.2: 24 h / -20 °C
3.1: zinc; titanium tetrachloride / tetrahydrofuran / 54 h / -78 - 23 °C
4.1: 3,3-dimethyldioxirane / tetrahydrofuran; acetone / 0.5 h / -78 °C / Green chemistry
4.2: 5 h / 23 °C / Green chemistry
With
dmap; 3,3-dimethyldioxirane; titanium tetrachloride; triethylamine; zinc;
In
tetrahydrofuran; water; acetone;
DOI:10.1016/j.tetlet.2015.01.084
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: triethylamine / water / 5 h / 23 °C
1.2: Reflux
2.1: triethylamine; dmap / tetrahydrofuran / 0.25 h / 23 °C
2.2: 24 h / -20 °C
3.1: zinc; titanium tetrachloride / tetrahydrofuran / 54 h / -78 - 23 °C
4.1: 3,3-dimethyldioxirane / tetrahydrofuran; acetone / 0.5 h / -78 °C / Green chemistry
4.2: 5 h / 23 °C / Green chemistry
With
dmap; 3,3-dimethyldioxirane; titanium tetrachloride; triethylamine; zinc;
In
tetrahydrofuran; water; acetone;
DOI:10.1016/j.tetlet.2015.01.084
