1H-Indole-4-acetaldehyde, 3-methyl-1-[(4-methylphenyl)sulfonyl]-7-(phenylmethoxy)-5-[[tris(1-methyl ethyl)silyl]oxy]-

Base Information

Chemical Name:1H-Indole-4-acetaldehyde, 3-methyl-1-[(4-methylphenyl)sulfonyl]-7-(phenylmethoxy)-5-[[tris(1-methyl ethyl)silyl]oxy]-
CAS No.:925463-63-4
Molecular Formula:C₃₄H₄₃NO₅SSi
Molecular Weight:605.871
Hs Code.:

Synonyms:

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Chemical Property of 1H-Indole-4-acetaldehyde, 3-methyl-1-[(4-methylphenyl)sulfonyl]-7-(phenylmethoxy)-5-[[tris(1-methyl ethyl)silyl]oxy]-

Chemical Property:

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Technology Process of 1H-Indole-4-acetaldehyde, 3-methyl-1-[(4-methylphenyl)sulfonyl]-7-(phenylmethoxy)-5-[[tris(1-methyl ethyl)silyl]oxy]-

There total 12 articles about 1H-Indole-4-acetaldehyde, 3-methyl-1-[(4-methylphenyl)sulfonyl]-7-(phenylmethoxy)-5-[[tris(1-methyl ethyl)silyl]oxy]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: N-[6-benzyloxy-2-(1-methyl-2-oxo-ethyl)-3-(2-oxo-ethyl)-4-triisopropylsilanyloxy-phenyl]-4-methyl-benzenesulfonamide

: 925463-63-4
[7-benzyloxy-3-methyl-1-(toluene-4-sulfonyl)-5-triisopropylsilanyloxy-1H-indol-4-yl]-acetaldehyde

Guidance literature:: With sulfuric acid; In tetrahydrofuran; for 5h;
DOI:10.1021/jo062064j

Reference yield:

: 925463-43-0
4-amino-3-benzyloxy-phenol

: 925463-63-4
[7-benzyloxy-3-methyl-1-(toluene-4-sulfonyl)-5-triisopropylsilanyloxy-1H-indol-4-yl]-acetaldehyde

Guidance literature:: Multi-step reaction with 8 steps

1: 84 percent / pyridine / CH₂Cl₂ / 4 h / 20 °C

2: 96 percent / sodium periodate on silica gel / CH₂Cl₂ / 4 h

3: CH₂Cl₂ / 15 h / 20 °C

4: 3.08 g / 1,8-diazabicyclo[5.4.0]undec-7-ene / CH₂Cl₂ / 0.33 h / 0 °C

5: 94 percent / sodium hydride / tetrahydrofuran / 0 - 20 °C

6: osmium tetroxide; N-methylmorpholine N-oxide / tetrahydrofuran; H₂O

7: sodium periodate on silica gel / CH₂Cl₂ / 2 h

8: 3.00 g / sulfuric acid / tetrahydrofuran / 5 h

With pyridine; sodium periodate; osmium(VIII) oxide; sulfuric acid; sodium hydride; 4-methylmorpholine N-oxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; dichloromethane; water; 3: Diels-Alder reaction;
DOI:10.1021/jo062064j

Reference yield:

: 221615-94-7
3-(benzyloxy)-4-nitrophenol

: 925463-63-4
[7-benzyloxy-3-methyl-1-(toluene-4-sulfonyl)-5-triisopropylsilanyloxy-1H-indol-4-yl]-acetaldehyde

Guidance literature:: Multi-step reaction with 9 steps

1: sodium borohydride; nickel(II) chloride hexahydrate / tetrahydrofuran; methanol

2: 84 percent / pyridine / CH₂Cl₂ / 4 h / 20 °C

3: 96 percent / sodium periodate on silica gel / CH₂Cl₂ / 4 h

4: CH₂Cl₂ / 15 h / 20 °C

5: 3.08 g / 1,8-diazabicyclo[5.4.0]undec-7-ene / CH₂Cl₂ / 0.33 h / 0 °C

6: 94 percent / sodium hydride / tetrahydrofuran / 0 - 20 °C

7: osmium tetroxide; N-methylmorpholine N-oxide / tetrahydrofuran; H₂O

8: sodium periodate on silica gel / CH₂Cl₂ / 2 h

9: 3.00 g / sulfuric acid / tetrahydrofuran / 5 h

With pyridine; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; sulfuric acid; sodium hydride; 4-methylmorpholine N-oxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; nickel dichloride; In tetrahydrofuran; methanol; dichloromethane; water; 4: Diels-Alder reaction;
DOI:10.1021/jo062064j